Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms
Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms
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DOI：
10.1007/s00415-012-6801-2
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发表时间：
2013-05-01
影响因子：
6
通讯作者：
Benarroch, Eduardo E.
中科院分区：
文献类型：
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作者：
Cersosimo, Maria G.;Raina, Gabriela B.;Benarroch, Eduardo E.
与对照受试者相比，评估帕金森病 (PD) 中胃肠道症状 (GIS) 的患病率及其出现时间与运动症状发作的关系。在 PD 的早期阶段，肠神经系统中存在 α-突触核蛋白 (α-SYN) 神经病理学的头尾梯度，上消化道的负担高于下消化道。然而，只有便秘被认为是帕金森病的运动前胃肠道表现。 129 名 PD 患者和 120 名对照者接受了结构化调查问卷，以评估 GIS 的存在，以及 PD 患者出现运动表现的时间。 PD患者中GIS明显更常见的是口干、流口水、吞咽困难、便秘和排便功能障碍。便秘和排便功能障碍先于运动表现。尽管胃轻瘫症状先于运动表现，但其患病率与对照组没有显着差异。尽管有证据表明上肠道有较高的 α-SYN 负担，但只有便秘和排便功能障碍是 PD 的显着运动前 GIS。
To assess the prevalence of gastrointestinal symptoms (GIS) in Parkinson's disease (PD) compared to control subjects and their timing of appearance in relationship to the onset of motor symptoms. There is a rostrocaudal gradient of alpha-synuclein (alpha-SYN) neuropathology in the enteric nervous system at early stages of PD with higher burden in the upper than the lower gut. However, only constipation has been recognized as a premotor gastrointestinal manifestation of PD. 129 PD patients and 120 controls underwent a structured questionnaire to assess the presence of GIS and, in PD patients, the time of their appearance respect to the onset of motor manifestations. GIS significantly more prevalent in PD patients were dry mouth, drooling, dysphagia, constipation and defecatory dysfunction. Constipation and defecatory dysfunction preceded motor manifestations. Whereas gastroparesis symptoms preceded motor manifestations, their prevalence was not significantly different from controls. Despite evidence of a higher alpha-SYN burden in the upper gut, only constipation and defecatory dysfunction were prominent premotor GIS of PD.