Epstein-Barr virus shedding by astronauts during space flight
Epstein-Barr virus shedding by astronauts during space flight
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DOI：
10.1016/j.bbi.2004.08.001
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发表时间：
2005-05-01
影响因子：
15.1
通讯作者：
Mehta, SK
中科院分区：
文献类型：
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作者：
Pierson, DL;Stowe, RP;Mehta, SK
通过量化eb病毒的脱落，研究了32名宇航员和18名年龄匹配的健康对照者的eb病毒（EBV）再激活模式。在为期5-14天的10次航天飞机任务之前，期间和之后收集了宇航员的唾液样本。在某个时间点，在每个宇航员的唾液中检测到EBV。对32名宇航员的1398份唾液样本进行聚合酶链反应分析，结果显示314份（23%）EBV DNA阳性。飞行阶段检测显示，28名宇航员在飞行前采集的唾液样本中有29%的EBV DNA呈阳性，25名宇航员在飞行期间采集的唾液样本中有16%，23名宇航员在飞行后采集的唾液样本中有16%呈阳性。从飞行期间采集的样本中获得的EBV副本的平均数量为每毫升417份，显著高于(p
Patterns of Epstein-Barr virus (EBV) reactivation in 32 astronauts and 18 healthy age-matched control subjects were characterized by quantifying EBV shedding. Saliva samples were collected from astronauts before, during, and after 10 space shuttle missions of 5-14 days duration. At one time point or another, EBV was detected in saliva from each of the astronauts. Of 1398 saliva specimens from 32 astronauts, polymerase chain reaction analysis showed that 314 (23%) were positive for EBV DNA. Examination by flight phase showed that 29% of the saliva specimens collected from 28 astronauts before flight were positive for EBV DNA, as were 16% of those collected from 25 astronauts during flight and 16% of those collected after flight from 23 astronauts. The mean number of EBV copies from samples taken during the flights was 417 per mL, significantly greater (p