Indoor cold exposure and nocturia: a cross-sectional analysis of the HEIJO-KYO study.
Indoor cold exposure and nocturia: a cross-sectional analysis of the HEIJO-KYO study.
复制标题
室内寒冷暴露与夜尿：HEIJO-KYO 研究的横断面分析。
作者：
Saeki K;Obayashi K;Kurumatani N.
目的探讨室内寒冷暴露与老年人群夜尿患病率之间的关系。对象和方法测量了1065名居家老年志愿者（年龄≥60岁）的客厅和卧室温度，持续48小时。夜尿（每晚≥2次排尿）和夜间尿产量分别通过排尿日记和夜间尿收集来确定。ResultsThe平均值±参与者的年龄为71.9 ± 7.1岁，夜尿的患病率为30.8%。白天室内温度降低1 °C与高风险比（OR）相关。（1.075，95%置信区间[CI] 1.026-1.126; P= 0.002），与室外温度和其他潜在混杂因素（如基本特征）无关（年龄、性别、体重指数、饮酒、吸烟）、合并症（糖尿病、肾功能不全）、药物（钙通道阻滞剂、利尿剂、安眠药）、社会经济状况（教育，家庭收入），夜间动态血压下降，白天体力活动，客观测量的睡眠效率，和尿6-硫酸氧褪黑激素排泄。校正夜间排尿率后，两者的相关性仍然显著（OR 1.095 [95%CI 1.042-1.150];P< 0.001）。这种关联的解释可能是冷诱导的逼尿肌过度活动。通过改善室内热环境，可以降低热过敏的发生率。
ObjectivesTo investigate the association between indoor cold exposure and the prevalence of nocturia in an elderly population.Subjects and MethodsThe temperature in the living rooms and bedrooms of 1 065 home‐dwelling elderly volunteers (aged ≥60 years) was measured for 48 h. Nocturia (≥2 voids per night) and nocturnal urine production were determined using a urination diary and nocturnal urine collection, respectively.ResultsThe mean ±sdage of participants was 71.9 ± 7.1 years, and the prevalence of nocturia was 30.8%. A 1 °C decrease in daytime indoor temperature was associated with a higher odds ratio (OR) for nocturia (1.075, 95% confidence interval [CI] 1.026–1.126;P= 0.002), independently of outdoor temperature and other potential confounders such as basic characteristics (age, gender, body mass index, alcohol intake, smoking), comorbidities (diabetes, renal dysfunction), medications (calcium channel blocker, diuretics, sleeping pills), socio‐economic status (education, household income), night‐time dipping of ambulatory blood pressure, daytime physical activity, objectively measured sleep efficiency, and urinary 6‐sulphatoxymelatonin excretion. The association remained significant after adjustment for nocturnal urine production rate (OR 1.095 [95% CI 1.042–1.150];P< 0.001).ConclusionsIndoor cold exposure during the daytime was independently associated with nocturia among elderly participants. The explanation for this association may be cold‐induced detrusor overactivity. The prevalence of nocturia could be reduced by modification of the indoor thermal environment.