Employment as butcher and cancer risk in a record-linkage study from Sweden
Employment as butcher and cancer risk in a record-linkage study from Sweden
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DOI：
10.1023/a:1008947531573
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发表时间：
2000-08-01
影响因子：
2.3
通讯作者：
Fraumeni, JF
中科院分区：
文献类型：
--
作者：
Boffetta, P;Gridley, G;Fraumeni, JF
目的：调查癌症的风险在屠夫和其他肉类工人在一个大的记录，从Sweden.Methods的联动研究：瑞典癌症环境登记III包含全国范围内的数据癌症发病率在1971-1989年的所有居民，职业和行业的就业报告在1960年和1970年的人口普查。我们在两次人口普查中确定了25，049名被归类为屠夫或肉类工人的男性。在排除了与动物直接接触的工人后，我们将剩余的男性劳动人口作为对照组。肉类行业的屠夫患癌症的风险略有增加（相对风险[RR] 1.1，95%置信区间[CI] 1.0-1.3），这是由于口腔和咽部癌症的风险增加（RR 1.6，95% CI 1.0-2.7）、胃（RR 1.6，95% CI 1.1-2.7）、喉（RR 1.4，95% CI 0.6-3.4）和肺（RR 1.4，95% CI 1.1-1.9）。胃癌的风险在研究的前5年是最高的，在城市地区的屠夫中。肺癌风险没有时间或地理变化，仅限于鳞状细胞癌的升高。在肉类行业以外的屠夫和肉类工人中，胃癌、喉癌和肺癌的风险增加。有没有明确的迹象表明，增加风险的其他肿瘤。结论：增加风险的口腔。瑞典屠夫中的喉癌、肺癌和胃癌可能至少部分是由于吸烟、饮酒和其他生活方式因素的混淆。然而，肉类行业的暴露（例如，病毒、亚硝胺、多环芳烃）可能会增加患癌症的风险。
Objective: To investigate the risk of cancer among butchers and other meat workers in a large record-linkage study from Sweden.Methods: The Swedish Cancer Environment Register III contains nationwide data on cancer incidence during 1971-1989 for all residents, by occupation and industry of employment as reported at the 1960 and 1970 censuses. We identified 25,049 men classified as butchers or meat workers at either census. We used as a comparison group the remaining part of the active male population, after exclusion of workers with direct contact with animals.Results: Butchers in the meat industry had a slight increase in the risk of cancer (relative risk [RR] 1.1, 95% confidence interval [CI] 1.0-1.3), which was due to an increased risk of cancers of the oral cavity and pharynx (RR 1.6, 95% CI 1.0-2.7), stomach (RR 1.6, 95% CI 1.1-2.7), larynx (RR 1.4, 95% CI 0.6-3.4), and lung (RR 1.4, 95% CI 1.1-1.9). The risk of stomach cancer was highest during the first 5 years of the study, and among butchers from urban areas. No temporal or geographic variations were seen for lung cancer risk, with elevations restricted to squamous cell carcinoma. An increased risk of stomach, laryngeal and lung cancers was present in butchers and meat workers outside the meat industry. There was no clear indication of an increased risk of other neoplasms.Conclusions: The increased risk of oral. laryngeal, lung and stomach cancers among Swedish butchers may be at least partly due to confounding by tobacco smoking, alcohol drinking, and other lifestyle factors. However, exposures in the meat industry (e.g., viruses, nitrosamines, polycyclic aromatic hydrocarbons) may contribute the elevated cancer risks.