Aging of the human cerebellum: A stereological study
Aging of the human cerebellum: A stereological study
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DOI：
10.1002/cne.10884
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发表时间：
2003-11-17
影响因子：
2.5
通讯作者：
Pakkenberg, B
中科院分区：
文献类型：
--
作者：
Andersen, BB;Gundersen, HJG;Pakkenberg, B
用体视学方法对19例19~84岁正常高加索男性的小脑进行了研究。小脑分为四个不同的区域：前叶和后叶、蚯蚓和绒毛结节叶。计算小脑皮质和白质的总体积、小脑表面积、蒲肯野细胞总数和颗粒细胞数，以及蒲肯野细胞及其核团的体积分布。随着年龄的增长，整体白质减少26%；浦肯野细胞体平均体积减少33%，而浦肯野细胞核的体积没有减少。有小脑总体积减少16%的趋势，但没有伴随的神经元丢失。普肯野细胞总数为28×10(6)(变异系数为0.16)，颗粒细胞总数为109×10(9)(CV=0.17)。然而，随着年龄的增长，在前叶观察到一个显著的变化，在那里发现选择性的浦肯野细胞和颗粒细胞都有40%的损失。此外，在主要参与运动控制的前叶记录到了30%的容量损失，主要是由于皮质容量的损失。(C)2003年Wiley-Liss，Inc.
Cerebella from 19 normal Caucasian males, ages 19-84 years, were studied using stereological methods. Cerebellum was divided into four different regions: the anterior and posterior lobe, the vermis, and the flocculonodular lobe. Total volume of the cerebellar cortex and white matter, cerebellar surface area, total Purkinje and granule cell number, and the distribution of the volumes of the Purkinje cells and their nuclei were estimated in all four regions. The global white matter was reduced by 26% with age; the mean volume of the Purkinje cell body was decreased by 33% with no decrease in the volume of the Purkinje cell nuclei. A tendency towards a 16% total cerebellar volume loss was seen without a concomitant neuron loss. No global Purkinje or granule cell loss was detected with age, total Purkinje cell number being 28 X 10(6) (coefficient of variation, CV = 0.16) and total granule cell number 109 X 10(9) (CV = 0.17). However, a significant change was observed with age in the anterior lobe, where a selective 40% loss of both Purkinje and granule cells was found. Furthermore, a 30% loss of volume, mostly due to a cortical volume loss, was recorded in the anterior lobe, which is predominantly involved in motor control. (C) 2003 Wiley-Liss, Inc.