Lifestyle factors and hip arthrosis - A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women
Lifestyle factors and hip arthrosis - A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women
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DOI：
10.3109/17453679708996687
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发表时间：
1997-06-01
期刊：
影响因子：
--
通讯作者：
Malchau, H
中科院分区：
文献类型：
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作者：
Vingard, E;Alfredsson, L;Malchau, H
我们在一项病例对照研究中调查了女性髋关节关节炎与生活方式因素（如体重指数（BMI）、吸烟和激素治疗）之间的关系。这项研究包括1991-1994年居住在瑞典5个县和5个镇的50-70岁的所有妇女。这些病例（230例）是因原发性关节病而行全髋关节置换术（THR）的女性，参照对象（273例）是从研究基础中随机选择的无髋关节问题的女性。所有女性都接受了关于身高、体重、吸烟习惯、激素治疗、体育活动、职业史、家庭作业等方面的采访，直到50岁。50岁后发生髋关节病导致THR的相对风险与BMI增加有关，在40岁时BMI大于等于25的患者中，报告的最高值为2.9 （CI 1.3-6.5）。减肥的预防价值似乎很大。吸烟者的风险为1.5 (CI 1.0-2.2)，高于非吸烟者。使用避孕药意味着THR的相对风险增加，而雌激素替代的风险低于未接触者。
We investigated in a case-referent study the relationship between arthrosis of the hip in women and lifestyle factors such as body mass index (BMI), smoking and hormone therapy.The study comprised all women of ages 50-70 years, living in 5 counties and 5 towns in Sweden 1991-1994. The cases (n 230) were women with total hip replacements (THR) because of primary arthrosis, and the referents (n 273) were randomly selected women from the study base, without hip problems. All women were interviewed about height, weight, smoking habits, hormone therapy, sports activities, occupational history, home work, etc, to the age of 50.The relative risk of developing hip arthrosis leading to a THR after the age of 50 was associated with an increased BMI, The highest value, 2.9 (CI 1.3-6.5), was reported in those with BMI greater than or equal to 25 at the age of 40. The preventive value of weight loss seems substantial. There was a greater risk of 1.5 (CI 1.0-2.2) for smokers than for non-smokers, Use of contraceptive pills meant an increase in the relative risk for THR, unlike estrogen substitution which was associated with a lower risk than in unexposed persons.