Comparison of focally induced epileptiform activities in C57BL/6 and BALB/c mice by using in vivo EEG recording
Comparison of focally induced epileptiform activities in C57BL/6 and BALB/c mice by using in vivo EEG recording
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DOI：
10.1016/j.neulet.2011.09.030
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发表时间：
2011-10-24
影响因子：
2.5
通讯作者：
Cansu, Ali
中科院分区：
文献类型：
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作者：
Aydin-Abidin, Selcen;Yildirim, Mehmet;Cansu, Ali
以反复发作为特征的癫痫受遗传因素的影响。近交系小鼠的癫痫反应取决于各种刺激，包括化学刺激(如五四氮唑、尼古丁、可卡因、NMDA、海人藻酸盐)、物理刺激(如听觉刺激)或电刺激。在这项研究中，我们比较了C57BL/6和BALB/c小鼠品系对青霉素诱发的癫痫样活动(一种局灶性癫痫模型)的易感性，通过分析棘波起始潜伏期、棘波幅度和棘波频率。并对基线脑电的功率谱进行了研究。我们没有发现C57和BALB小鼠之间的棘波起始潜伏期的变化。然而，BALB小鼠的尖峰电位幅度和尖峰频率高于C57小鼠。在脑电功率谱方面，两个品系的调查谱带的绝对功率没有差异。有趣的是，所有被研究的条带的相对功率在两个菌株之间有显著的差异。与BALB小鼠相比，C57小鼠的Delta和theta的相对功率较低，而α、β和伽马的相对功率较高。综上所述，我们的研究结果表明，与C57株相比，BALB小鼠对青霉素诱导的癫痫样活动更敏感。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Epilepsy characterized by repeated seizures is influenced by genetic factors. Seizure response of inbred mouse strains changes depending on the variety of stimuli including chemical (e.g., pentylenetetrazole, nicotine, cocaine, NMDA, kainate), physical (e.g., auditory) or electrical. In this study, we compared the susceptibilities of C57BL/6 and BALB/c mice strains to penicillin induced epileptiform activity (a focally induced, experimental epilepsy model), by analyzing the spike onset latency, spike amplitude and spike frequency. The power spectrums of baseline EEGs were also investigated. We found no alterations of spike onset latencies between the C57 and BALB mice. However, spike amplitudes and spike frequencies were found to be higher in BALB mice than C57 mice. With regard to EEG power spectrum, absolute power of investigated bands was not different between the two strains. Interestingly, the relative power of all investigated bands differed significantly between two strains. The relative power of delta and theta was lower whereas relative power of alpha, beta and gamma was higher in C57 mice compared to BALB mice. In conclusion, our findings showed that BALB mice are more sensitive to penicillin induced epileptiform activity when compared to C57 strain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.