BACTERIAL ADHERENCE - ADHESION-RECEPTOR INTERACTIONS MEDIATING THE ATTACHMENT OF BACTERIA TO MUCOSAL SURFACES
BACTERIAL ADHERENCE - ADHESION-RECEPTOR INTERACTIONS MEDIATING THE ATTACHMENT OF BACTERIA TO MUCOSAL SURFACES
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DOI：
10.1093/infdis/143.3.325
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发表时间：
1981-01-01
影响因子：
6.4
通讯作者：
BEACHEY, EH
中科院分区：
文献类型：
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作者：
BEACHEY, EH
最近的研究表明，细菌附着在粘膜表面是大多数由细菌引起的动物和人类传染病发病的初始事件。对细菌(粘附素)表面和宿主细胞膜(受体)表面黏附分子的理解和对黏附分子定义的了解，为预防严重细菌感染提出了新的方法：(1)应用纯化的黏附素或受体材料或其类似物作为细菌黏附的竞争性抑制剂；(2)给药亚致死浓度的抗生素，以抑制细菌黏附素的形成和表达；(3)开发针对参与黏附到粘膜表面的细菌表面成分的疫苗。针对几种人类细菌病原体的菌毛粘附素的抗粘连疫苗的开发已经取得了进展。
Recent studies have indicated that the attachment of bacteria to mucosal surfaces is the initial event in the pathogenesis of most infectious diseases due to bacteria in animals and humans. An understanding of the mechanisms of attachment and a definition of the adhesive moleculeson the surfaces of bacteria (adhesins) as wellas those on host cell membranes (receptors) have suggested new approaches to the prevention of serious bacterial infections: (1) application of purified adhesin or receptor materials or their analogues as competitive inhibitors of bacterial adherence; (2) administration of sublethal concentrations of antibiotics that suppress the formation and expression of bacterial adhesins; and (3) development of vaccines against bacterial surface components involved in adhesion to mucosal surfaces. Progress has already been made in the development of antiadhesive vaccines directed against the fimbrial adhesins of several human bacterial pathogens.