Thymopoiesis in elderly human is associated with systemic inflammatory status

Thymopoiesis in elderly human is associated with systemic inflammatory status
复制标题

DOI：
10.1007/s11357-008-9084-x
复制
发表时间：
2009-06-01
期刊：
AGE
影响因子：
--
通讯作者：
Leal, Manuel
Leal, Manuel
中科院分区：
医学2区
文献类型：
--
作者：
Ferrando-Martinez, Sara;Franco, Jaime M.;Leal, Manuel

文献摘要

被引文献

相似文献

针对年龄相关的免疫系统损伤的免疫衰老研究集中于临床淋巴细胞减少情况或雄激素阻断，揭示了关于成人免疫重建的新见解。然而，据我们所知，老年人胸腺中淋巴细胞生成的程度仍不清楚。为此，我们分析了65例成人胸腺（36 ~ 81岁，中位年龄68.6岁），这些胸腺来自接受心脏手术的患者。我们的研究结果表明，CD 4（+）CD 8（+）双阳性（DP）细胞和年龄（倒数）和百分比（直接）的外周幼稚T细胞之间的相关性，表明胸腺仍然能够影响外周淋巴细胞池，即使在老年人。我们还发现胸腺生成的程度和炎症标志物之间的显着相关性，如DP和中性粒细胞的百分比和IL-6水平和外周淋巴细胞的百分比之间的负相关性所示。此外，在多元线性回归中，DP和IL-7水平的百分比，而不是年龄，与中性粒细胞的百分比独立相关。总之，即使在老年人中，胸腺也保持着活跃的胸腺生成，使外周幼稚T细胞池恢复活力。此外，年龄相关的胸腺生成衰退与外周炎症标志物有关。
Immunosenescence studies of age-related immune system damage focused on clinical lymphopenic situations or androgenic blockade have revealed new insights about adult human immune reconstitution. However, as far as we know, the extent of lymphopoiesis in the thymus of elderly humans remains unclear. To this effect, we have analyzed 65 adult human thymuses (from 36 to 81 years; median age 68.6 years) obtained from patients who underwent cardiac surgery. Our results show a correlation between CD4(+)CD8(+) double-positive (DP) cells and both the age (inverse) and percentage (direct) of peripheral naive T cells, indicating that the thymus is still able to affect the peripheral lymphocyte pool even in the elderly. We also found significant correlation between the degree of thymopoiesis and the inflammation markers, as shown by the inverse correlations between DP and the percentage of neutrophils and IL-6 levels and the percentage of peripheral lymphocytes. Furthermore, in a multivariate linear regression the percentage of DP and IL-7 levels, but not age, were independently associated with the percentage of neutrophils. In conclusion, the thymus maintains, even in the elderly, an active thymopoiesis that rejuvenates the peripheral naive T-cell pool. Moreover, age-related thymopoietic decay is associated with the peripheral inflammation markers.