Weight change and all-cause, cancer and cardiovascular disease mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study
Weight change and all-cause, cancer and cardiovascular disease mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study
复制标题
DOI：
10.1038/ijo.2009.234
复制
发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Tsugane, S.
中科院分区：
文献类型：
--
作者：
Nanri, A.;Mizoue, T.;Tsugane, S.
背景资料：目前尚不清楚亚洲人群成年期的体重变化是否会影响随后的死亡率，他们具有相对较瘦的体重。目的：评估日本男性和女性5年以上的体重变化与全因、癌症和心血管疾病死亡率的关系。设计：受试者为36220名男性和44091名女性，年龄在45 - 75岁之间，基线时无严重疾病史。体重变化计算为两次调查之间的体重与5年interval.Results的差异：在699 963人年的后续行动中，我们确定了4232全因死亡，1872癌症死亡和1021心血管死亡。体重变化与全因死亡率呈倒J型关系。多变量风险比体重减轻5 kg或以上与体重变化小于2.5 kg的（95%置信区间）分别为1.62（1.45-1.81），女性为1.76（1.51-2.05），而体重增加5 kg或以上时，男性为1.40（1.22-1.59），女性为1.25（1.02-1.54）。即使排除了前3年随访中的死亡，这些相关性仍具有统计学意义。体重变化与死亡率的关系在体重不足者或不吸烟的男性中很明显。无论是男性还是女性，体重减轻5公斤或以上的癌症死亡风险都会增加。关于心血管疾病，死亡风险往往增加与体重减轻在男性和女性，而其增加与体重增加只观察到在women.Conclusions：一个大的体重变化，无论是损失和增益，与死亡的风险增加。体重减轻和增加可能是健康成年日本人早期死亡的预测因子。International Journal of Obesity（2010）34，348-356; doi：10.1038/ijo.2009.234; 2009年11月17日在线发表
Background: It is unclear whether weight change during adulthood influences subsequent mortality in Asian populations, who have a relatively lean body mass.Objective: To assess the relation of weight change over 5 years to all-cause, cancer and cardiovascular disease mortality among Japanese men and women.Design: Subjects were 36 220 men and 44 091 women aged between 45 and 75 years without a history of serious disease at baseline. Weight change was calculated as the difference of body weight between two surveys with a 5-year interval.Results: During 699 963 person-years of follow-up, we identified 4232 deaths of all-cause, 1872 cancer deaths and 1021 cardiovascular deaths. The relation between weight change and all-cause mortality was reverse J-shaped. Multivariate hazard ratios (95% confidence interval) for weight loss of 5 kg or more versus weight change of less than 2.5 kg were 1.62 (1.45-1.81) in men and 1.76 (1.51-2.05) in women, whereas those for weight gain of 5 kg or more were 1.40 (1.22-1.59) in men and 1.25 (1.02-1.54) in women. These associations remained statistically significant even after the exclusion of deaths in the first 3 years of follow-up. The weight change-mortality association was pronounced in underweight persons or in nonsmoking men. The risk of cancer mortality increased in both men and women who lost weight by 5 kg or more. With regard to cardiovascular disease, mortality risk tended to increase with weight loss both in men and women, whereas its increase with weight gain was observed only in women.Conclusions: A large weight change, both loss and gain, was associated with an increased risk of mortality. Weight loss and gain may be predictors of early death in apparently healthy adult Japanese. International Journal of Obesity ( 2010) 34, 348-356; doi: 10.1038/ijo.2009.234; published online 17 November 2009