Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer.
Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer.
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基于癌症多药耐药机制的紫杉烷类纳米药物输送。
DOI：
10.1016/j.biotechadv.2014.10.011
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发表时间：
2015
影响因子：
16
通讯作者：
Chen, Meiwan
中科院分区：
文献类型：
--
作者：
Qiu, Jiange;Shi, Zhi;Wang, Yitao;Chen, Meiwan
紫杉烷类是治疗癌症最广泛使用的化疗剂之一。然而，它们的临床应用受到内在和获得性耐药性的严重限制。紫杉烷耐药的机制多种多样，如药物靶点的改变、外排转运蛋白的过度表达、凋亡机制的缺陷和药物转运的障碍。随着对紫杉烷类耐药分子机制认识的不断深入，产生了许多逆转耐药的靶点。然而，克服紫杉烷类药物耐药性不仅具有治疗潜力，而且面临着临床挑战，这加速了最佳纳米给药系统的发展。本文综述了紫杉烷类耐药机制的研究进展，并对各种逆转紫杉烷类耐药的纳米给药系统进行了综合分析。
Taxanes are one type of the most extensively used chemotherapeutic agents to treat cancers. However, their clinical use is severely limited by intrinsic and acquired resistance. A diverse variety of mechanisms has been implicated about taxane resistance, such as alterations of drug targets, overexpression of efflux transporters, defective apoptotic machineries, and barriers in drug transport. The deepening understanding of molecular mechanisms of taxane resistance has spawned a number of targets for reversing resistance. However, circumvention of taxane resistance would not only possess therapeutic potential, but also face with clinical challenge, which accelerates the development of optimal nanoscale delivery systems. This review highlights the current understanding on the mechanisms of taxane resistance, and provides a comprehensive analysis of various nanoscale delivery systems to reverse taxane resistance.
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影响因子：
6.2
作者：
Tang, Jingling;Wang, Yongjun;Wang, Dun;Wang, Yuhua;Xu, Zhenghong;Racette, Kelly;Liu, Feng
通讯作者：
Liu, Feng
影响因子：
9.7
作者：
Yangqing Zhang;L. Tang;Leilei Sun;Junbo Bao;Cunxian Song;Laiqiang Huang;Kexin Liu;Yan Tian
通讯作者：
Yangqing Zhang;L. Tang;Leilei Sun;Junbo Bao;Cunxian Song;Laiqiang Huang;Kexin Liu;Yan Tian
影响因子：
4.9
作者：
Liu Y;Huang L;Liu F
通讯作者：
Liu F
影响因子：
5.7
作者：
Takahashi, T;Yamasaki, F;Ueno, NT
通讯作者：
Ueno, NT
影响因子：
4.6
作者：
Oida K;Matsuda A;Jung K;Xia Y;Jang H;Amagai Y;Ahn G;Nishikawa S;Ishizaka S;Jensen-Jarolim E;Matsuda H;Tanaka A
通讯作者：
Tanaka A