Defensins: natural anti-HIV peptides.
Defensins: natural anti-HIV peptides.
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DOI：
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发表时间：
2004-07
期刊：
影响因子：
2.2
通讯作者：
Theresa L. Chang;M. Klotman
中科院分区：
文献类型：
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作者：
Theresa L. Chang;M. Klotman
哺乳动物防御素是小的阳离子抗菌肽，主要存在于参与宿主防御的白细胞和上皮细胞中。这些肽在先天免疫中充当效应分子，在适应性免疫中充当调节剂。越来越多的证据表明防御素是 HIV-1 的有效抑制剂。虽然 HIV-1 感染者的防御素水平尚未确定，但与 HIV 疾病进展相关的中性粒细胞减少和中性粒细胞功能障碍可能会导致 α-防御素产生改变。本综述概述了防御素的结构和功能，重点介绍了防御素的抗 HIV-1 活性及其作用机制。尽管仍然存在许多问题，但研究防御素在针对 HIV 的先天免疫中的复杂功能对于我们进一步了解疾病进展以及开发新的预防和治疗方法具有重要意义。
Mammalian defensins are small cationic antimicrobial peptides predominantly found in leukocytes and epithelial cells engaged in host defense. These peptides act as effector molecules in innate immunity as well as regulators in adaptive immunity. Increasing evidence indicates that defensins are effective inhibitors of HIV-1. While the level of defensins in HIV-1 infected individuals has not been determined, neutropenia and neutrophil dysfunction associated with HIV disease progression may result in altered alpha-defensin production. This review provides an overview of the structure and function of defensins, and focuses on the anti-HIV-1 activity of defensins and the mechanism of this activity. Although many questions remain, studying the complex function of defensins in innate immunity against HIV has implications for our further understanding of disease progression and for the development of novel approaches to prevention and therapy.