Agrammatic comprehension caused by a glioma in the left frontal cortex
Agrammatic comprehension caused by a glioma in the left frontal cortex
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DOI：
10.1016/j.bandl.2009.05.001
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发表时间：
2009-08-01
影响因子：
2.5
通讯作者：
Sakai, Kuniyoshi L.
中科院分区：
文献类型：
--
作者：
Kinno, Ryuta;Muragaki, Yoshihiro;Sakai, Kuniyoshi L.
已知左额下回（L，IFG）的病变并不总是引起Broca失语症，这使人怀疑该区域的特异性。我们先前设计了一个用于功能磁共振成像（fMRI）研究的图片-句子匹配任务，并观察到两个三角部（L。F3t）。IFG（延伸至盖部（LF 3 op））和左侧运动前区皮质（L. LPMC）选择性地参与句法加工。本研究采用病变-症状映射的方法来检验这些区域的功能是否对句法理解起关键作用。使用相同的图片-句子匹配任务，我们检查了21例左额叶皮层胶质瘤患者，但在口头/书面交流或智商方面没有明显的残疾。该任务包括三个主要的句子类型条件：规范/主谓主动句、非规范/主谓被动句和非规范/宾语混杂句。患者术前接受高分辨率3D-MRI检查，错误率数据采用基于体素的病变-症状映射。我们发现L. F3 op/F3 t或L。LPMC表现出不同模式的条件选择性赤字的理解句子。更具体地说，L. F3 op/F3 t受损的患者在非规范句子的理解方面有更严重的缺陷，而L。LPMC受损的患者在理解以对象开头的混乱句子方面有更深刻的缺陷。这些结果表明，L F3 op/F3 t或L. LPMC足以引起语法理解。(C)2009 Elsevier Inc. All rights reserved.
It has been known that lesions in the left inferior frontal gyrus (L, IFG) do not always cause Broca's aphasia, casting doubt upon the specificity of this region. We have previously devised a picture-sentence matching task for a functional magnetic resonance imaging (fMRI) study, and observed that both pars triangularis (L. F3t) of L. IFG (extending to pars opercularis (L F3op)) and the left lateral premotor cortex (L. LPMC) are selectively involved in syntactic processing. The present study with lesion-symptoms mapping was conducted to examine whether the function of these regions is indeed critical for syntactic comprehension. Using the same picture-sentence matching task, we examined 21 patients with a glioma in the left frontal cortex but with no apparent disability in verbal/written communication or intelligence quotient. This task included three main conditions of sentence types: canonical/subject-initial active sentences, non-canonical/subject-initial passive sentences, and non-canonical/object-initial scrambled sentences. The patients preoperatively underwent a high-resolution 3D-MRI, and voxel-based lesion-symptom mapping was employed for the error rates data. We found that the patients with a lesion in L. F3op/F3t or L. LPMC showed differential patterns of condition-selective deficits in the comprehension of sentences. More specifically, the L. F3op/F3t-damaged patients had more profound deficits in the comprehension of non-canonical sentences, whereas the L. LPMC-damaged patients had more profound deficits in the comprehension of object-initial scrambled sentences. These results establish that a lesion in L F3op/F3t or L. LPMC is sufficient to cause agrammatic comprehension. (C) 2009 Elsevier Inc. All rights reserved.