Efflux pumps and drug resistance in gram-negative bacteria
Efflux pumps and drug resistance in gram-negative bacteria
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DOI：
10.1016/0966-842x(94)90654-8
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发表时间：
1994-01-01
影响因子：
15.9
通讯作者：
Nikaido, Hiroshi
中科院分区：
文献类型：
--
作者：
Ma, Dzwokai;Cook, David N.;Nikaido, Hiroshi
革兰氏阴性菌的外膜只能减缓亲脂性抑制剂的流入，因此这些细菌需要广泛特异性的主动外排泵才能生存。泵，如大肠杆菌Acr系统及其同系物，使革兰氏阴性菌耐染料，洗涤剂和抗生素。
The outer membrane of Gram-negative bacteria can only slow down the influx of lipophilic inhibitors, and so these bacteria need active efflux pumps of broad specificity to survive. Pumps such as theEscherichia coliAcr system and its homologs make Gram-negative bacteria resistant to dyes, detergents and antibiotics.