Co-occurrence of liver metastasis of gastrointestinal stromal tumor and hepatocellular carcinoma: a case report.
Co-occurrence of liver metastasis of gastrointestinal stromal tumor and hepatocellular carcinoma: a case report.
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DOI：
10.1186/s40792-016-0212-z
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发表时间：
2016-12
影响因子：
0.8
通讯作者：
Baba H
中科院分区：
文献类型：
--
作者：
Yamashita K;Baba Y;Kurashige J;Iwatsuki M;Imai K;Hashimoto D;Sakamoto Y;Chikamoto A;Yoshida N;Beppu T;Baba H
胃肠道间质瘤（GIST）是一种潜在的恶性间质肿瘤，可引起远处转移，主要发生在肝脏。同时发生原发性肝肿瘤（例如，肝细胞癌（HCC）在GIST患者中极为罕见。本文报告一位77岁男性病人，原发于小肠的胃肠道间质瘤合并肝转移，同时合并肝癌。患者3年前因原发性GIST接受小肠切除术，1年前因GIST肝转移接受部分肝切除术和射频消融术。尽管继续使用伊马替尼进行辅助治疗，但通过随访计算机断层扫描检测到肝脏中的两个新病变，其中一个肿瘤逐渐增大。进行了第二次肝切除术。病理检查发现一个肿瘤是GIST的肝转移，另一个是原发性肝癌。据我们所知，这是第一个报告的同时并存的肝转移的胃肠道间质瘤和原发性肝癌。
Gastrointestinal stromal tumors (GISTs) are potentially malignant mesenchymal tumors that can give rise to distant metastases, mainly in the liver. The co-occurrence of synchronous primary liver tumors (e.g., hepatocellular carcinoma (HCC)) in patients with GIST is extremely rare. This report describes a 77-year-old male patient with liver metastasis of GIST originating in the small intestine and synchronous HCC. The patient had undergone resection of the small intestine for the primary GIST 3 years earlier and partial hepatectomy and radiofrequency ablation for liver metastases of GIST 1 year earlier. Despite the continuation of adjuvant therapy with imatinib, two new lesions in the liver were detected by follow-up computed tomography scanning, which showed the gradual enlargement of one tumor. A second hepatectomy was performed. Pathological examination revealed that one tumor was a liver metastasis of GIST and the other was a primary HCC. To our knowledge, this is the first report of the synchronous co-occurrence of a liver metastasis of GIST and a primary HCC.