Mechanisms of Light-induced Liposome Permeabilization.
Mechanisms of Light-induced Liposome Permeabilization.
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DOI：
10.1002/btm2.10032
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发表时间：
2016-09
影响因子：
7.4
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Miranda D;Lovell JF
脂质体已被广泛研究用于药物递送应用。将光敏分子包含在脂质体中打开了光控货物释放的可能性，以增强药物在靶位点的生物分布或生物利用度。由光诱导的膜透化可以是一种有效的策略，用于增强具有空间和时间控制的货物递送，其具有化学光治疗方法的潜力。已经报道了几种不同的机制，包括光诱导氧化、光交联、光异构化、光裂解和光热释放。在这里，我们回顾了最近的一些关于脂质体光触发货物释放的报道。
Liposomes have been widely studied for drug delivery applications. The inclusion of photoactive molecules into liposomes opens the possibility of light‐controlled cargo release to enhance drug biodistribution or bioavailability at target sites. Membrane permeabilization induced by light can be an effective strategy for enhancing cargo delivery with spatial and temporal control, which holds potential for chemophototherapy approaches. Several diverse mechanisms have been reported including light‐induced oxidation, photocrosslinking, photoisomerization, photocleavage, and photothermal release. Here, we review selected recent reports of light‐triggered cargo release from liposomes.