Weight change during lactation does not alter the concentrations of chlorinated organic contaminants in breast milk of women with low exposure.
Weight change during lactation does not alter the concentrations of chlorinated organic contaminants in breast milk of women with low exposure.
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DOI：
10.1177/089033449901500408
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发表时间：
1999-12-01
期刊：
影响因子：
--
通讯作者：
Dewey, K G
中科院分区：
文献类型：
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作者：
Lovelady, C A;Whitehead, R A;Dewey, K G
这项纵向研究的目的是评估产后 4 至 20 周哺乳期间体脂的减少是否会增加母乳中环境污染物的浓度。我们在两个不同的纯母乳喂养女性群体中研究了这种关系：(1) 接触污染物较少的加州女性（n = 10，体重稳定[平均变化，0.0 +/- 0.2 kg]，n = 11 体重减轻[平均减轻，-4.1 +/- 0.4 kg]）和 (2) 西班牙裔女性 (n = 30)，她们最近主要从墨西哥移民到北卡罗来纳州，据推测患有之前接触污染物的次数较多。对母乳样本进行了六氯苯 (HCB) 和 DDT 及其相关产品的分析。加州或北卡罗来纳州女性的身体成分变化与牛奶污染物浓度变化之间没有显着关系。加利福尼亚州和北卡罗来纳州女性的 HCB 浓度相似，但北卡罗来纳州受试者的 DDT 和相关产品浓度较高。结果表明，接触环境污染物较少的哺乳期妇女适度减轻体重不会增加母乳中污染物的浓度。
The purpose of this longitudinal study was to evaluate whether a loss of body fat during lactation between 4 and 20 wk postpartum increases the concentration of environmental contaminants in breast milk. We examined this relationship in two different cohorts of exclusively breastfeeding women: (1) California women with low exposure to contaminants (n = 10 whose weight was stable [mean change, 0.0 +/- 0.2 kg] and n = 11 who lost weight [mean loss, -4.1 +/- 0.4 kg]) and (2) Hispanic women (n = 30) who had recently immigrated to North Carolina, primarily from Mexico, and were presumed to have a higher prior exposure to contaminants. Breast milk samples were analyzed for hexachlorobenzene (HCB) and DDT and its related products. There was no significant relationship between change in body composition and change in milk contaminant concentrations in either California or North Carolina women. Concentrations of HCB were similar between the California and North Carolina women, but those of DDT and related products were higher in the North Carolina subjects. Results suggest that moderate weight loss in lactating women with low exposure to environmental contaminants does not increase contaminant concentration in breast milk.