Renovation of epithermal neutron beam for BNCT at THOR
Renovation of epithermal neutron beam for BNCT at THOR
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DOI：
10.1016/j.apradiso.2004.05.042
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发表时间：
2004-11-01
影响因子：
1.6
通讯作者：
Liu, HM
中科院分区：
文献类型：
--
作者：
Liu, YWH;Huang, TT;Liu, HM
2003年1月，台湾的雷神(清华开放池反应堆)因更新新的超热中子束而关闭，准备用于临床试验。2003年11月，混凝土切割完成，距离岩芯更近，处理室更大。本文介绍了新梁施工的设计依据。沿光束方向的滤光片/慢化器设计为Cd(0.1 cm)+Al(10 Cm)+FUENTAL(TM)(16 Cm)+Al(10 Cm)+FUENTAL(24 Cm)+VOID(18 Cm)+Cd(0.1 cm)+Bi(10 Cm)，反射器为6 cm的铅。在滤光片/慢化剂之后是一个88厘米长、6厘米厚的双线准直器，其末端是Li2CO3-PE。准直器周围是Li2CO3-PE和铅。计算得到2 mW束流出口的束流参数为：Phi(Epi)=3.4×10(9)n/cm(2)/S，D-f/Phi(Epi)=2.8×10(-11)cGycm(2)/n，D-Gamma/Phi(Epi)=1.3×10(-11)cGycm(2)/n，J(+)/Phi=0.8。对于距射束出口10 cm的体模，MCNP计算表明，当肿瘤和正常组织中的硼浓度分别为65和18ppm时，模型的优势深度为8.9 cm，优势比为5.6。正常组织的最大剂量率为50cGy/min。最大治疗比为6。梁的建造计划于2004年4月底完成。(C)2004爱思唯尔有限公司。保留所有权利。
Heading for possible use for clinical trial, THOR (Tsing Hua Open-pool Reactor) at Taiwan was shutdown for renovation of a new epithermal neutron beam in January 2003. In November 2003, concrete cutting was finished for closer distance from core and larger treatment room. This article presents the design base that the construction of the new beam is based on. The filter/moderator design along the beam is Cd(0.1 cm) + Al(10 cm) + FLUENTAL(TM)(16 cm) + Al(10 cm) + FLUENTAL(24 cm) + Void(18 cm) + Cd(0.1 cm) + Bi(10 cm) with 6 cm Pb as reflector. Following the filter/moderator is an 88 cm long, 6 cm thick Bi-lined collimator with Li2CO3-PE at the end. The collimator is surrounded by Li2CO3-PE and Pb. The calculated beam parameters under 2 MW at the beam exit is phi(epi) = 3.4 x 10(9) n/cm(2)/s, D-f/phi(epi) = 2.8 x 10(-11) cGy cm(2)/n, D-gamma/phi(epi) = 1.3 x 10(-11) cGy cm(2)/n, and J(+)/phi = 0.8. For a phantom placed 10 cm from beam exit, MCNP calculation shows that the advantage depth is 8.9 cm, and advantage ratio is 5.6 if boron concentration in tumor and normal tissue are assumed to be 65 and 18 ppm. The maximum dose rate for normal tissue is 50 cGy/min. The maximum therapeutic ratio is 6. The construction of the beam is scheduled to be finished by the end of April 2004. (C) 2004 Elsevier Ltd. All rights reserved.