TT virus infection in Japanese children: isolates from genotype 1 are overrepresented in patients with hepatic dysfunction of unknown etiology.
TT virus infection in Japanese children: isolates from genotype 1 are overrepresented in patients with hepatic dysfunction of unknown etiology.
复制标题
日本儿童中的 TT 病毒感染：基因型 1 的分离株在病因不明的肝功能障碍患者中比例过高。
DOI：
10.1620/tjem.191.233
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Y. Wada
中科院分区：
文献类型：
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作者：
K. Sugiyama;K. Goto;T. Ando;F. Mizutani;K. Terabe;T. Yokoyama;Y. Wada
TT病毒（TTV）的致病性，特别是在儿童时期仍然不清楚。我们调查了40例非A至C型肝功能障碍患者（非A至C型肝功能障碍组）中TTV的患病率。本研究纳入了5例不明原因的重型肝炎患者。我们还检查了380名没有输血或肝病史的儿童（对照组）。随后，根据其核苷酸序列（包括开放阅读框架1区的222 bp）分析分离的TTV株的基因型。非A ~ C型肝功能异常组血清TTVDNA阳性率为10/40（25%），对照组为25/380（7%）。66%（23/35）的所有检查病例表现出基因型1或2。然而，非A至C肝功能障碍组（10例）的基因型评估显示，基因型1的患病率高于所有其他基因型（80%对20%）。这一结果与对照组（25例; 32% vs. 68%）有显著差异。基因型1的这种过度表达表明，这种类型的TTV株与日本儿童病因不明的肝功能障碍的发展有关。
The pathogenecity of the TT virus (TTV) especially during childhood remains obscure. We investigated the prevalence of TTV in 40 patients with non-A to C hepatic dysfunction (non-A to C hepatic dysfunction group). Five patients with fulminant hepatitis of unknown etiology were enrolled in this group. We also examined 380 children without a history of transfusion or liver disease (control group). Subsequently, the genotypes of TTV strains isolated were analyzed in terms of their nucleotide sequences including 222 bp in the open reading frame 1 region. The prevalence of serum TTV DNA was 10/40 (25%) in the non-A to C hepatic dysfunction group and 25/380 (7%) in the control group. Sixty-six percent (23/35) of all examined cases exhibited either genotype 1 or 2. However, assessment of genotype in the non-A to C hepatic dysfunction group (10 cases) revealed a higher prevalence of genotype 1 than of all other genotypes (80% vs. 20%). This result differed significantly from that of the control group (25 cases; 32% vs. 68%). Such overrepresentation of genotype 1 suggests that this type of TTV strain is associated with the development of hepatic dysfunction of unknown etiology in Japanese children.