Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis
Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis
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DOI：
10.1182/blood.v101.7.2473
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发表时间：
2003-04-01
期刊：
影响因子：
20.3
通讯作者：
Rollins, BJ
中科院分区：
文献类型：
--
作者：
Fleming, MD;Pinkus, JL;Rollins, BJ
已有研究表明，趋化因子受体表达的改变是朗格汉斯细胞从皮肤向淋巴组织迁移的基础。被激活的细胞被认为下调CCR6，其配体巨噬细胞炎症蛋白-3α(MIP-3α)/CCL20在皮肤中表达，上调CCR7，其配体在淋巴组织中。在朗格汉斯细胞组织细胞增生症(LCH)中，病理性朗格汉斯细胞(LCS)聚集在多个组织中，包括皮肤、骨骼和淋巴器官。我们对24例LCH进行了检查，发现病理性LCS同时表达CCR6和CCR7。此外，MIP-3α/CCL20在受累皮肤中由角质形成细胞表达，在受累骨质中由巨噬细胞和成骨细胞表达。病理性LC中CCR6的表达可能与其在皮肤、骨骼等非淋巴组织中的蓄积有关，而CCR7的表达则可能将其导向淋巴组织。Rosai-Dorfman病和噬血细胞综合征的组织细胞也共表达CCR6和CCR7，提示这可能是异常组织细胞的一般属性。
It has been suggested that a switch in chemokine receptor expression underlies Langerhans cell migration from skin to lymphoid tissue. Activated cells are thought to down-regulate CCR6, whose ligand macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 is expressed in skin, and up-regulate CCR7, whose ligands are in lymphoid tissues. In Langerhans cell histiocytosis (LCH), pathologic Langerhans cells (LCs) accumulate in several tissues, including skin, bone, and lymphoid organs. We have examined 24 LCH cases and find that pathologic LCs expressed CCR6 and CCR7 coincidentally in all cases. Furthermore, MIP-3alpha/CCL20 is expressed by keratinocytes in involved skin and by macrophages and osteoblasts in involved bone. Expression of CCR6 by pathologic LCs may contribute to their accumulation in nonlymphoid organs such as skin and bone, whereas CCR7 expression may direct them to lymphoid tissue. Histiocytes in Rosai-Dorfman disease and hemophagocytic syndrome also coexpressed CCR6 and CCR7, suggesting that this may be a general attribute of abnormal histiocytes.