Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis
Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis
复制标题
DOI：
10.21873/anticanres.15094
复制
发表时间：
2021-06
影响因子：
2
通讯作者：
T. Arigami;Daisuke Matsushita;K. Okubo;K. Sasaki;Yusuke Tsuruda;Y. Kita;S. Mori;Shigehiro Yanagita;Y. Uenosono;H. Kurahara;T. Ohtsuka
中科院分区：
文献类型：
--
作者：
T. Arigami;Daisuke Matsushita;K. Okubo;K. Sasaki;Yusuke Tsuruda;Y. Kita;S. Mori;Shigehiro Yanagita;Y. Uenosono;H. Kurahara;T. Ohtsuka
背景/目的：探讨以人表皮生长因子受体2(HER2)表达为基础的曲妥珠单抗化疗对胃癌腹主动脉旁淋巴结(PAN)转移患者预后的影响。患者和方法：对41例接受化疗的胃癌临床泛转移患者进行回顾性研究。结果：18例(43.9%)患者HER2阳性，因此接受了曲妥珠单抗化疗。共有11名患者接受了手术。HER2状态与远处转移灶的数量、有无基于曲妥珠单抗的化疗以及有无胃切除显著相关。HER2阳性患者的预后明显好于HER2阴性患者。多变量分析表明，年龄和基于HER2状态的曲妥珠单抗化疗是一个独立的预后因素。结论：评估HER2的表达及后续的曲妥珠单抗化疗可作为判断胃癌PAN转移患者预后的有效方法。
Background/Aim: To determine the prognostic utility of trastuzumab-based chemotherapy based on human epidermal growth factor receptor 2 (HER2) expression in patients with para-aortic lymph node (PAN) metastasis from gastric cancer. Patients and Methods: A total of 41 patients with clinical PAN metastasis from gastric cancer who underwent chemotherapy were retrospectively enrolled. Results: Eighteen (43.9%) patients had HER2-positive tumors and consequently, received trastuzumab-based chemotherapy. A total of 11 patients underwent surgery. HER2 status was significantly correlated with the number of distant metastatic sites, the presence or absence of trastuzumab-based chemotherapy, and the presence or absence of gastrectomy. HER2-positive patients had significantly better prognosis than HER2-negative patients. Multivariate analysis identified age and trastuzumab-based chemotherapy based on HER2 status as an independent prognostic factor. Conclusion: Assessing HER2 expression and subsequent trastuzumab-based chemotherapy can be an effective method for determining the prognosis of patients with PAN metastasis from gastric cancer.