Analysis of granulocyte beta-adrenergic response in cystic fibrosis: correlation of decreased responsiveness with disease severity.
Analysis of granulocyte beta-adrenergic response in cystic fibrosis: correlation of decreased responsiveness with disease severity.
复制标题
囊性纤维化中粒细胞β-肾上腺素能反应的分析：反应性下降与疾病严重程度的相关性。
DOI：
10.1164/arrd.1981.123.6.622
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Busse,WW
中科院分区：
文献类型：
--
作者：
LemanskeJr,RF;Mischler,EH;Farrell,PM;Anderson,C;Busse,WW
分离 21 名非哮喘性囊性纤维化 (CF) 患者的粒细胞，并测量异丙肾上腺素、组胺和前列腺素 E1up 对酵母聚糖诱导的 β-葡萄糖醛酸酶释放的影响。与对照受试者相比，CF 患者的粒细胞总 β-葡萄糖醛酸酶活性明显较低，但对酵母聚糖刺激的反应正常。与对照组相比，患有严重气道疾病的CF患者（％预测FEV1<60）的粒细胞对异丙肾上腺素的反应显着降低，这与％预测FEV1值和NIH临床评分相关。在同一 CF 患者群体中，与对照受试者相比，粒细胞对 PGE1 的反应性也有所降低，但损害程度不像异丙肾上腺素观察到的那么严重，也与疾病严重程度无关。然而，组胺反应是正常的。我们的研究结果表明，异常的β-肾上腺素能反应可能反映了气道疾病和临床评分的严重程度。
Granulocytes from 21 nonasthmatic cystic fibrosis (CF) patients were isolated and the effects of isoproterenol, histamine, and prostaglandin E1upon zymosan-induced beta-glucuronidase release was measured. Granulocytes from CF patients contained significantly less total beta-glucuronidase activity compared with those from control subjects, but response to zymosan stimulation was normal. Compared with those from control subjects, the granulocytes from CF patients with severe airway disease (% predicted FEV1<60) had significantly reduced responsiveness to isoproterenol, which correlated with both the % predicted FEV1values and the NIH clinical score. In this same population of CF patients, granulocyte responsiveness to PGE1was also decreased compared with that of the control subjects, but the degree of impairment was not as severe as that observed with isoproterenol nor did it correlate with disease severity. Histamine responsiveness, however, was normal. Our findings suggest that abnormal beta-adrenergic responses may reflect the severity of airway disease and clinical score.