CHARACTERIZATION OF SPONTANEOUS COLITIS IN COTTON-TOP TAMARINS (SAGUINUS-OEDIPUS) AND ITS RESPONSE TO SULFASALAZINE
CHARACTERIZATION OF SPONTANEOUS COLITIS IN COTTON-TOP TAMARINS (SAGUINUS-OEDIPUS) AND ITS RESPONSE TO SULFASALAZINE
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DOI：
10.1016/s0016-5085(85)80126-8
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
WINTER, HS
中科院分区：
文献类型：
--
作者：
MADARA, JL;PODOLSKY, DK;WINTER, HS
棉铃虫慢性结肠炎(CTT)的特征是在非衰弱的活体CTT中获取远端结肠活检标本、血细胞、血清蛋白和粪便进行细菌学和寄生虫检查。通过获取10只其他灵长类动物的远端结肠活检标本进行组织学检查，评估了CTT中观察到的结肠炎组织学特征的物种特异性。活动性结肠炎的组织学证据在50%的成人结肠炎中被发现，但在所有研究的非结肠性结肠炎中都没有。从18个CTTS采集的42份粪便标本中仅检出一株(弯曲杆菌)。除了活动性结肠炎外，CTT直肠黏膜还经常有微妙的粘膜结构异常，这在非相关灵长类物种中是不存在的，可能代表慢性结肠炎。未见上皮化生。采用随机10wk安慰剂对照交叉试验，评价口服磺胺吡啶(50 mg/kg·d)治疗CTT结肠炎的疗效。这项研究表明，与生理盐水对照组相比，柳氮磺吡啶治疗显著改善了疾病活动性(p<；0.05)，显著增加了动物体重(p<；0.01)和血清白蛋白(p<；0.01)。柳氮磺胺吡啶疗法可以改善这种疾病的影响，并为未来的研究保持这种濒危物种的实验群体提供了希望。
Chronic colitis in the cotton-top tamarin (CTT) has been characterized by obtaining distal colonic biopsy specimens, hematocrits, serum albumins, and stools for bacteriologic and parasitic examination in nondebilitated living CTTs. The species specificity of the histologic features of colitis observed in the CTT was assessed by obtaining distal colonic biopsy specimens from 10 animals of other primate species for histologic examination. Histologic evidence of active colitis was found in 50% of adult CTTs but was absent in all non-CTT species studied. Fortytwo stool samples obtained from 18 CTTs yielded only one isolate (Campylobacter). In addition to active colitis, CTT rectal mucosa also often had subtle irregularities in mucosal structure that were not present in nonrelated primate species and might represent chronic colitis. Metaplasia was not observed. The therapeutic effects of oral sul f asalazine (50 mg/kg · day) on CTT colitis were assessed in a randomized 10-wk placebo controlled crossover study. This study demonstrated significant improvement in disease activity as judged histologically (p< 0.05) and significant increases in animal weight (p< 0.01) and serum albumin (p< 0.01) during sulfasalazine therapy when compared with saline control. Sulfasalazine therapy can ameliorate the effects of this disease and offers promise in maintaining experimental colonies of this endangered species for future studies.