TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function.
TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function.
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TCRdb：具有强大搜索功能的T细胞受体序列综合数据库
DOI：
10.1093/nar/gkaa796
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Guo AY
中科院分区：
文献类型：
--
作者：
Chen SY;Yue T;Lei Q;Guo AY
T细胞和T细胞受体（TCR）库在免疫应答和免疫治疗中起着关键作用。TCR测序（TCR- seq）技术能够准确地分析TCR序列，目前大量的TCR- seq数据是公开的。基于有效重用这些数据的迫切需要，我们通过统一的管道在TCR- seq数据上对TCR序列进行表征，开发了TCRdb，这是一个综合性的人类TCR序列数据库。TCRdb包含超过2.77亿个高可靠的TCR序列，来自数百种组织/临床条件/细胞类型的8265个TCR- seq样本。TCRdb的独特之处在于：(1)通过严格统一的TCRdb流水线生成不同样本中全面可靠的TCR库序列；（ii）强大的搜索功能，允许用户在不同条件下识别自己感兴趣的TCR序列；（iii）分类样本元数据，对不同样本类型的tcr进行比较；（iv）交互式数据可视化图表，描述了TCR多样性、长度分布和V-J基因利用的TCR库。TCRdb数据库可在http://bioinfo.life.hust.edu.cn/TCRdb/上免费获得，将成为T细胞免疫学研究和应用社区的有用资源。
Abstract T cells and the T-cell receptor (TCR) repertoire play pivotal roles in immune response and immunotherapy. TCR sequencing (TCR-Seq) technology has enabled accurate profiling TCR repertoire and currently a large number of TCR-Seq data are available in public. Based on the urgent need to effectively re-use these data, we developed TCRdb, a comprehensive human TCR sequences database, by a uniform pipeline to characterize TCR sequences on TCR-Seq data. TCRdb contains more than 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples across hundreds of tissues/clinical conditions/cell types. The unique features of TCRdb include: (i) comprehensive and reliable sequences for TCR repertoire in different samples generated by a strict and uniform pipeline of TCRdb; (ii) powerful search function, allowing users to identify their interested TCR sequences in different conditions; (iii) categorized sample metadata, enabling comparison of TCRs in different sample types; (iv) interactive data visualization charts, describing the TCR repertoire in TCR diversity, length distribution and V-J gene utilization. The TCRdb database is freely available at http://bioinfo.life.hust.edu.cn/TCRdb/ and will be a useful resource in the research and application community of T cell immunology.
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影响因子：
8.7
作者：
Corrie BD;Marthandan N;Zimonja B;Jaglale J;Zhou Y;Barr E;Knoetze N;Breden FMW;Christley S;Scott JK;Cowell LG;Breden F
通讯作者：
Breden F
DOI：
10.1084/jem.20161318
发表时间：
2017-03-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Levine AG;Hemmers S;Baptista AP;Schizas M;Faire MB;Moltedo B;Konopacki C;Schmidt-Supprian M;Germain RN;Treuting PM;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
7.3
作者：
Christley S;Scarborough W;Salinas E;Rounds WH;Toby IT;Fonner JM;Levin MK;Kim M;Mock SA;Jordan C;Ostmeyer J;Buntzman A;Rubelt F;Davila ML;Monson NL;Scheuermann RH;Cowell LG
通讯作者：
Cowell LG
影响因子：
17.1
作者：
de Masson A;O'Malley JT;Elco CP;Garcia SS;Divito SJ;Lowry EL;Tawa M;Fisher DC;Devlin PM;Teague JE;Leboeuf NR;Kirsch IR;Robins H;Clark RA;Kupper TS
通讯作者：
Kupper TS
TCR-Seq 和 RNA-Seq 数据的超灵敏 T 细胞受体检测方法
影响因子：
5.8
作者：
Chen, Si-Yi;Liu, Chun-Jie;Guo, An-Yuan
通讯作者：
Guo, An-Yuan