Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan NIPPON DATA90
Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan NIPPON DATA90
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DOI：
10.1253/circj.70.954
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发表时间：
2006-08-01
影响因子：
3.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Nakamura, Koshi;Okamura, Tomonori;Ueshima, Hirotsugu
背景慢性肾脏病（CKD）已被确定为心血管疾病（CVD）的危险因素。方法和结果心血管死亡的风险进行了评估，在一个大的队列的参与者随机选择的日本总人口。参与者（平均年龄52.4岁）无既往CVD，随访10年。使用克利夫兰诊所实验室为肾脏疾病饮食改良研究开发的简化方程估计肾小球滤过率（GFR）。在7，316名参与者中，6.7%患有CKD，基线时GFR < 60。即使在调整其他危险因素后，CKD的存在也会增加心血管死亡的风险，风险比为1.20（95%置信区间，0.82-1.76）。此外，GFR与心血管死亡风险之间的负相关性被观察到：60岁以下儿童为1.09（0.72-1.64）。
Background Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD).Methods and Results The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR < 60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60