Serum and tissue levels of teicoplanin during cardiac surgery: the effect of a high dose regimen.
Serum and tissue levels of teicoplanin during cardiac surgery: the effect of a high dose regimen.
复制标题
心脏手术期间替考拉宁的血清和组织水平：高剂量方案的影响。
DOI：
10.1093/jac/23.4.613
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
R. Grüneberg
中科院分区：
文献类型：
--
作者：
A. Wilson;S. Shankar;D. Felmingham;T. Treasure;R. Grüneberg
两项前瞻性试验表明，替考拉宁在预防心脏手术后革兰氏阳性伤口感染方面不如氟氯西林和氨基糖苷类药物的组合有效。初始剂量400 mg与手术结束时脂肪中替考拉宁的亚抑制浓度有关。在这项研究中，研究了10名患者在冠状动脉手术期间给予较高初始剂量(12 mg/kg)的行为。与先前的试验一样，在24小时后再次注射400 mg。体外循环结束时，血清、脂肪和皮肤中的平均浓度分别为15 mg/L、6 mg/kg和9 mg/kg，均超过葡萄球菌的预期临界点(4 mg/L)。在外科预防中，高剂量方案可能更为成功。
Two prospective trials suggested that teicoplanin was less effective in preventing Gram-positive wound infections after cardiac surgery than a combination of flucloxacillin and an aminoglycoside. The initial dose of 400 mg was associated with a subinhibitory concentration of teicoplanin in fat at the end of operation. In this study, the behaviour of a higher initial dose (12 mg/kg) was investigated in ten patients during coronary artery surgery. As in the earlier trials, a second dose (400 mg) was given after 24 h. The mean concentration at the end of cardiopulmonary bypass was 15 mg/l in serum, 6 mg/kg in fat and 9 mg/kg in skin, all in excess of the expected break-point for staphylococci (4 mg/l). The higher dose regimen might be more successful in surgical prophylaxis.