Entropy analysis of the EEG background activity in Alzheimer's disease patients
Entropy analysis of the EEG background activity in Alzheimer's disease patients
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DOI：
10.1088/0967-3334/27/3/003
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发表时间：
2006-03-01
影响因子：
3.2
通讯作者：
Poza, J
中科院分区：
文献类型：
--
作者：
Abásolo, D;Hornero, R;Poza, J
阿尔茨海默病（Alzheimer's disease，AD）是最常见的神经退行性疾病。虽然确诊只能通过尸检，但应尝试与其他类型的痴呆症和重度抑郁症进行鉴别诊断。本研究的目的是分析AD患者的脑电图（EEG）背景活动，以验证AD患者EEG的规律性高于同龄对照组的假设。我们记录了11例AD患者和11名年龄匹配的对照者的19个头皮电极的EEG。两种不同的方法被用来估计EEG背景活动的规律性：频谱熵（SpecEn）和样本熵（SampEn）。我们没有发现AD患者和对照组的EEG与SpecEn之间的显着差异。另一方面，AD患者在电极P3、P4、O1和O2处的SampEn值显著低于对照受试者（p < 0.01）。我们的研究结果显示AD患者的EEG规律性增加。这些研究结果表明，非线性分析的EEG与SampEn可以产生重要的信息，并可能有助于增加对AD的脑功能障碍的洞察力的方式，这是不可能与更经典和传统的统计方法。
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Although a definite diagnosis is only possible by necropsy, a differential diagnosis with other types of dementia and with major depression should be attempted. The aim of this study was to analyse the electroencephalogram (EEG) background activity of AD patients to test the hypothesis that the regularity of the AD patients' EEG is higher than that of age-matched controls. We recorded the EEG from 19 scalp electrodes in 11 AD patients and 11 age-matched controls. Two different methods were used to estimate the regularity of the EEG background activity: spectral entropy (SpecEn) and sample entropy (SampEn). We did not find significant differences between AD patients and control subjects' EEGs with SpecEn. On the other hand, AD patients had significantly lower SampEn values than control subjects (p < 0.01) at electrodes P3, P4, O1 and O2. Our results show an increase of EEG regularity in AD patients. These findings suggest that nonlinear analysis of the EEG with SampEn could yield essential information and may contribute to increasing the insight into brain dysfunction in AD in ways which are not possible with more classical and conventional statistical methods.