Fluoropyrimidine-Based Chemotherapy as First-Line Treatment for Advanced Gastric Cancer: a Bayesian Network Meta-Analysis
Fluoropyrimidine-Based Chemotherapy as First-Line Treatment for Advanced Gastric Cancer: a Bayesian Network Meta-Analysis
复制标题
基于氟嘧啶的化疗作为晚期胃癌的一线治疗：贝叶斯网络荟萃分析
DOI：
10.1007/s12253-016-0078-1
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发表时间：
2016-05
影响因子：
2.8
通讯作者：
Shenglin MA
中科院分区：
文献类型：
--
作者：
Lucheng Zhu;Jihong Liu;Shenglin MA
Fluoropyrimidine-based regimens are the most common treatments in advanced gastric cancer. We used a Bayesian network meta-analysis to identify the optimal fluoropyrimidine-based chemotherapy by comparing their relative efficacy and safety. We systematically searched databases and extracted data from randomized controlled trials, which compared fluoropyrimidine-based regimens as first-line treatment in AGC. The main outcomes were overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and grade 3 or 4 adverse events (AEs). A total of 12 RCTs of 4026 patients were included in our network meta-analysis. Pooled analysis showed S-1 and capecitabine had a significant OS benefit over 5-Fu, with hazard ratios of 0.90 (95%CI = 0.81–0.99) and 0.88 (95%CI = 0.80–0.96), respectively. The result also exhibited a trend that S-1 and capecitabine prolonged PFS in contrast to 5-Fu, with hazard ratios of 0.84 (95%CI = 0.66–1.02) and 0.84 (95%CI = 0.65–1.03), respectively. Additionally, all the three fluoropyrimidine-based regimens were similar in terms of ORR and grade 3 or 4 AEs. Compared with regimens based on 5-Fu, regimens based on S-1 or capecitabine demonstrated a significant OS improvement without compromise of AEs as first-line treatment in AGC in Asian population. S-1 and capecitabine can be interchangeable according their different emphasis on AEs.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
DOI：
--
发表时间：
1982-06
期刊：
Cancer treatment reports
影响因子：
--
作者：
G. Cocconi;V. Delisi;B. di Blasio
通讯作者：
G. Cocconi;V. Delisi;B. di Blasio
影响因子：
2.5
作者：
Tierney JF;Stewart LA;Ghersi D;Burdett S;Sydes MR
通讯作者：
Sydes MR
影响因子：
45.3
作者：
Webb, A;Cunningham, D;Meehan, M
通讯作者：
Meehan, M
影响因子：
6.7
作者：
Yoshida, R;Nakajima, M;Yokoi, T
通讯作者：
Yokoi, T