Antiviral activity of 2-amino-4, 4α-Dihydro-4α-7-dimethyl-3H-phenoxazine-3-one on poliovirus
Antiviral activity of 2-amino-4, 4α-Dihydro-4α-7-dimethyl-3H-phenoxazine-3-one on poliovirus
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2-氨基-4, 4α-二氢-4α-7-二甲基-3H-吩恶嗪-3-酮对脊髓灰质炎病毒的抗病毒活性
DOI：
10.1620/tjem.200.161
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发表时间：
2003
影响因子：
2.2
通讯作者：
A. Tomoda
中科院分区：
文献类型：
--
作者：
A. Iwata;Teruhide Yamaguchi;Kouei Sato;Ryutaro Izumi;A. Tomoda
由牛血红蛋白与2-氨基-5-甲基苯酚反应生成的2-氨基-4，4 α-二氢-4 α-7-二甲基-3H-吩恶嗪-3-酮（Phx）在0.25 ~ 2 μ g-/ml范围内抑制脊髓灰质炎病毒在Vero细胞中的增殖，在1 μg-/ml时达到最大抗病毒活性。这些结果表明，Phx可能是有用的，以防止脊髓灰质炎病毒感染的增殖。
2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 μg-/ml and 2 μg-/ml with maximal antiviral acitivity at 1 μg-/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.