Gene networks capable of pattern formation:: From induction to reaction-diffusion
Gene networks capable of pattern formation:: From induction to reaction-diffusion
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DOI：
10.1006/jtbi.2000.2092
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发表时间：
2000-08-21
影响因子：
2
通讯作者：
Solé, RV
中科院分区：
文献类型：
--
作者：
Salazar-Ciudad, I;Garcia-Fernández, J;Solé, RV
发育生物学的主要目标之一是了解单个看似同质的卵细胞如何实现成体的复杂结构。在此我们提出两种模型，通过基因层面的相互作用来解释发育模式的产生。一种模型考虑细胞间的直接接触诱导，而另一种则考虑激素的扩散。我们表明，包含相同基因网络且通过激素进行通讯的细胞群会自发地呈现出有序模式。我们已经对这些模式以及负责它们的特定网络进行了特征描述。这些模型能够（i）将扩散和直接接触诱导过程作为模式产生的机制进行比较；（ii）确定真实基因网络可能的行为范围；（iii）提出产生已知模式的因果机制。文中还讨论了其进化意义。（C）2000学术出版社
One of the main aims of developmental biology is to understand how a single and apparently homogeneous egg cell achieves the intricate complexity of the adult. Here we present two models to explain the generation of developmental patterns through interactions at the gene level. One model considers direct-contact induction between cells while the other takes into account diffusion of hormones. We show that sets of cells involving identical gene networks and communicating through hormones spontaneously exhibit ordered patterns. We have characterized these patterns and the specific networks responsible for them. The models allow to (i) compare diffusion and direct-contact induction processes as mechanisms of pattern generation; (ii) identify the possible range of behaviour of real gene networks and (iii) suggest causal mechanisms to generate known patterns. The evolutionary implications are discussed. (C) 2000 Academic Press.