Relationship between pubertal timing and body size in underfed male rats.
Relationship between pubertal timing and body size in underfed male rats.
复制标题
营养不足的雄性大鼠青春期时间与体型的关系。
DOI：
10.1210/endo-115-1-19
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发表时间：
1984
期刊：
影响因子：
4.8
通讯作者：
R. Vigersky
中科院分区：
文献类型：
--
作者：
A. Glass;J. Anderson;D. Herbert;R. Vigersky
通过临界体重和临界体脂假说，已经提出了身体大小和性成熟之间的直接联系。为了在雄性大鼠中验证这些理论，我们比较了由于营养不良而生长速度降低的动物与体重匹配但正常喂养的大鼠的性成熟程度。在研究的三个时间点：青春期早期（血清睾酮升高的近似时间）、青春期晚期（成熟精子细胞出现的近似时间）和青年期，营养不良大鼠的前列腺、精囊和睾丸重量显著大于体重匹配的正常喂养对照组。在第一个时间点，营养不良大鼠的睾丸，但不是那些正常喂养，体重匹配的对照，显示成熟的第19步精子细胞，血清睾酮显着较高的营养不良动物。在所有时间点，两组的血清LH水平相似，而在所有时间点，营养不良大鼠的血清FSH水平均显著降低。李指数，肥胖指数，在营养不良的大鼠中显着降低。目前的研究表明，尽管体脂肪百分比较低，但营养不良的大鼠比相同体重的正常喂养对照组性成熟。这些发现不支持雄性大鼠青春期的临界体重或临界体脂假设。
A direct connection has been proposed between body size and sexual maturation by the critical body weight and critical body fat hypotheses. To test these theories in male rats, we compared the degree of sexual maturation in animals with reduced growth rate due to undernutrition with that in weight-matched but normally fed rats. Underfed rats had significantly larger prostate, seminal vesicle, and testis weights than the weight-matched normally fed controls at the three time points studied: the early pubertal period (approximate time of onset of rising serum testosterone), late pubertal period (approximate time of appearance of mature spermatids), and young adult period. At the first time point, testes of underfed rats, but not those of normally fed, weight-matched controls, showed mature step 19 spermatids, and serum testosterone was significantly higher in the underfed animals. At all time points, serum LH levels were similar in both groups, while serum FSH levels were significantly lower in the underfed rats at all points. The Lee index, an index of fatness, was significantly lower in the underfed rats. The current study indicates that underfed rats are more sexually mature than normally fed controls of the same weight despite having a lower percentage of body fat. These findings do not support the critical body weight or critical body fat hypotheses of puberty in male rats.