Immunohistochemical localization of kallikrein within the prolactin-producing cells of the rat anterior pituitary gland.
Immunohistochemical localization of kallikrein within the prolactin-producing cells of the rat anterior pituitary gland.
复制标题
大鼠垂体前叶催乳素产生细胞内激肽释放酶的免疫组织化学定位。
DOI：
10.1677/joe.0.1270317
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
T. Noguchi
中科院分区：
文献类型：
--
作者：
K. Kizuki;A. Kitagawa;M. Takahashi;H. Moriya;M. Kudo;T. Noguchi
用大鼠尿激肽释放酶抗血清免疫组织化学技术，研究了组织激肽释放酶在大鼠脑垂体腺的定位。激肽释放酶阳性细胞在雌雄大鼠脑垂体前叶均可见，但在后叶未见阳性细胞。发情期雌性大鼠垂体前叶激肽释放酶阳性细胞与催乳素产生细胞相对应，而产生生长激素、黄体生成素和促肾上腺皮质激素的细胞则不表达激肽释放酶。因此，组织激肽释放酶可能参与催乳素的产生，而不是其他垂体前叶激素，如GH、LH、FSH、ACTH和TSH的产生。
The localization of tissue kallikrein in the pituitary gland of rats was investigated by an immunohistochemical technique using antiserum against rat urinary kallikrein. Kallikrein-positive cells were detected in the anterior lobe of the pituitary of both male and female rats, but were not observed in the posterior lobe of the pituitary in either sex. The kallikrein-positive cells in the anterior pituitary of female rats in oestrus were found to correspond to the prolactin-producing cells, whereas the cells producing GH, LH and ACTH were negative for kallikrein. It is possible, therefore, that the tissue kallikrein may be involved in the production of prolactin and not that of the other anterior pituitary hormones, such as GH, LH, FSH, ACTH and TSH.