Cell type specific tracing of the subcortical input to primary visual cortex from the basal forebrain.
Cell type specific tracing of the subcortical input to primary visual cortex from the basal forebrain.
复制标题
从基底前脑到初级视觉皮层的皮层下输入的细胞类型特异性追踪。
DOI：
10.1002/cne.24412
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lyon,DavidC
中科院分区：
文献类型：
--
作者：
Lean,GeorginaA;Liu,Yong-Jun;Lyon,DavidC
The basal forebrain provides cholinergic inputs to primary visual cortex (V1) that play a key modulatory role on visual function. While basal forebrain afferents terminate in the infragranular layers of V1, acetylcholine is delivered to more superficial layers through volume transmission. Nevertheless, direct synaptic contact in deep layers 5 and 6 may provide a more immediate effect on V1 modulation. Using helper viruses with cell type specific promoters to target retrograde infection of pseudotyped and genetically modified rabies virus evidence was found for direct synaptic input onto V1 inhibitory neurons. These inputs were similar in number to geniculocortical inputs and, therefore, considered robust. In contrast, while clear evidence for dorsal lateral geniculate nucleus input to V1 excitatory neurons was found, there was no evidence of direct synaptic input from the basal forebrain. These results suggest a direct and more immediate influence of the basal forebrain on local V1 inhibition.
