Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.
Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.
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DOI：
10.1016/j.mce.2009.07.001
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发表时间：
2009-10-30
影响因子：
4.1
通讯作者：
Gaddy D
中科院分区：
文献类型：
--
作者：
Nicks KM;Perrien DS;Akel NS;Suva LJ;Gaddy D
有细胞和物理证据表明，激活素和抑制素调节成骨细胞生成和骨质质发生，并且在体内调节骨骼量，尽管激活素和抑制素最初是从性腺中分离出来的，但也会在骨骼中产生并储存。通过内分泌效应的骨细胞分化和代谢。与经典性的立体定向是骨质量和骨骼强度的重要调节剂，在男性中，抑制蛋白的循环抑制剂在抑制素B中引起抑制素水平（音调）的暂时变化基本作用有可能取消抑制局部刺激成骨细胞生成和骨质质发生的变化，从而改变骨代谢。
There is both cellular and physiological evidence demonstrating that both Activins and Inhibins regulate osteoblastogenesis and osteoclastogenesis, and regulate bone mass in vivo. Although Activins and Inhibins were initially isolated from the gonad, Activins are also produced and stored in bone, whereas Inhibins exert their regulation on bone cell differentiation and metabolism via endocrine effects. The accumulating data provide evidence that reproductive hormones, distinct from classical sex steroids, are important regulators of bone mass and bone strength. Given the well described dominant antagonism of Inhibin over Activin, as well as over BMPs and TGFβ, the gonadally-derived Inhibins are important regulators of locally produced osteotrophic factors. Thus, the cycling Inhibins in females and diurnal changes in Inhibin B in males elicit temporal shifts in Inhibin levels (tone) that de-repress the pituitary. This fundamental action has the potential to de-repress locally stimulated changes in osteoblastogenesis and osteoclastogenesis, thereby altering bone metabolism.
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影响因子：
5.3
作者：
CENTRELLA, M;MCCARTHY, TL;CANALIS, E
通讯作者：
CANALIS, E
影响因子：
4.8
作者：
Gaddy-Kurten, D;Coker, JK;Manolagas, SC
通讯作者：
Manolagas, SC
影响因子：
2.7
作者：
Abid, Shadaan;Maitra, Anurupa;Gokral, Jyotsna
通讯作者：
Gokral, Jyotsna
DOI：
10.1016/s0960-0760(98)00145-9
发表时间：
1999-04-01
影响因子：
4.1
作者：
Burger, HG
通讯作者：
Burger, HG
影响因子：
4
作者：
Dolter, KE;Palyash, JC;Yu, J
通讯作者：
Yu, J