Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis.
Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis.
复制标题
代谢功能障碍相关的脂肪肝 (MAFLD) 和病毒性肝炎
DOI：
10.14218/jcth.2021.00200
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发表时间：
2022-02-28
影响因子：
3.6
通讯作者：
Xie Q
中科院分区：
文献类型：
--
作者：
Wang X;Xie Q
2020年提出了代谢功能障碍相关脂肪肝病（MAFLD）的新定义。从非酒精性脂肪肝病（NAFLD）到MAFLD的变化凸显了伴随脂肪肝的代谢异常。 MAFLD 的诊断不需要排除肝脏疾病和饮酒的继发性原因。因此，MAFLD 可能与其他类型的肝脏疾病共存，例如病毒性肝炎，这种疾病仍然是肝病相关死亡的最常见原因。随着MAFLD患病率的不断增加，临床上经常遇到同时患有MAFLD和病毒性肝炎的患者。在这篇综述中，我们主要总结了乙型/丙型肝炎与MAFLD相关的系统代谢功能障碍之间的相互关系。我们讨论 MAFLD 对病毒性肝炎进展和治疗的影响。还发现了一些与伴随的 MAFLD 和病毒性肝炎相关的尚未解决的临床问题。
A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed in 2020. The change from nonalcoholic fatty liver disease (NAFLD) to MAFLD highlights the metabolic abnormalities that accompany fatty liver. The diagnosis of MAFLD does not require exclusion of secondary causes of liver diseases and alcohol consumption. Thus, MAFLD may coexist with other types of liver diseases, such as viral hepatitis, a disease that remains the most common cause of liver disease-related death. With the increasing prevalence of MAFLD, patients with coincidental MAFLD and viral hepatitis are frequently encountered in clinical practice. In this review, we mainly summarize the mutual relationship between hepatitis B/C and systematic metabolism dysfunction related to MAFLD. We discuss the impact of MAFLD on progression of viral hepatitis and the therapies. Some unaddressed clinical problems related to concomitant MAFLD and viral hepatitis are also identified.