AMYLOID DEPOSITION IN THE NUCLEUS BASALIS OF MEYNERT COMPLEX - A TOPOGRAPHIC MARKER FOR DEGENERATING CELL CLUSTERS IN ALZHEIMERS-DISEASE
AMYLOID DEPOSITION IN THE NUCLEUS BASALIS OF MEYNERT COMPLEX - A TOPOGRAPHIC MARKER FOR DEGENERATING CELL CLUSTERS IN ALZHEIMERS-DISEASE
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DOI：
10.1007/bf00690530
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发表时间：
1988-01-01
影响因子：
12.7
通讯作者：
ARENDT, A
中科院分区：
文献类型：
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作者：
ARENDT, T;TAUBERT, G;ARENDT, A
在统称为Meynert复合体的基底核的不同基底前脑结构中出现的胆碱能皮质投射系统的缺陷是阿尔茨海默病中的常见发现，阿尔茨海默病是一种神经病理学特征为出现三种脑内形式的扭曲β-突触的疾病。折叠片（淀粉样蛋白）纤维、神经纤维缠结、含淀粉样蛋白的神经炎斑和嗜中性淀粉样蛋白血管病。在本研究中，在10例阿尔茨海默氏病中，研究了这种疾病的这些标志，淀粉样蛋白沉积和胆碱能基底前脑系统神经元丢失之间的定量关系。除了大脑皮层和海马体的持续受累外，所有阿尔茨海默病病例均显示内侧隔核、斜角带核和无名质中存在大量淀粉样蛋白，这与这些区域的神经元丢失相关。基底前脑的淀粉样沉积是由于与斑块和神经纤维缠结相关的嗜酸性血管病引起的。基底前脑中淀粉样蛋白沉积的分布完全局限于那些代表大脑皮层和海马胆碱能神经支配起源的神经元簇。直接相邻的结构不受影响。这些研究结果表明，在胆碱能基底前脑系统的退化机制中，淀粉样蛋白沉积具有致病作用。
The deficiency of the cholinergic cortical projection system arising in the different basal forebrain structures collectively referred to as nucleus basalis of Meynert complex is a constant finding in Alzheimer''s disease, a disorder which is neuropathologically characterised by the appearance of three intracerebral forms of twisted .beta.-pleated sheet (amyloid) fibrils, neurofibrillary tangles, amyloid-containing neuritic plaques and congophilic amyloid angiopathy. In the present study the quantitative relationship between these hallmarks of the disease, amyloid deposition and neuronal loss in the cholinergic basal forebrain system, was investigated in ten cases of Alzheimer''s disease. Besides a constant involvement of the cerebral cortex and hippocampus, all cases of Alzheimer''s disease show a large amount of amyloid in the medial septal nucleus, in the diagonal band nucleus and in the substantia innominata which is correlated with neuronal loss in these areas. These amyloid deposits in the basal forebrain are due to congophilic angiopathy associated with plaques and neurofibrillary tangles. The distribution of amyloid deposition in the basal forebrain is restricted entirely to those neuronal clusters which represent the origin of cholinergic innervation of the cerebral cortex and hippocampus. Immediately adjacent structures are not affected. These findings suggest a pathogenetic role of amyloid deposition in the mechanism of degeneration of the cholinergic basal forebrain system.