Inheritance of immunoglobulin E: genetic model fitting.
Inheritance of immunoglobulin E: genetic model fitting.
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免疫球蛋白E的遗传：遗传模型拟合。
DOI：
10.1002/ajmg.1320140110
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Marsh,DG
中科院分区：
文献类型：
--
作者：
Hasstedt,SJ;Meyers,DA;Marsh,DG
对通过乳腺癌先证者选出的 5 个家系的 316 名成员进行了总血清免疫球蛋白 E (IgE) 浓度的测量。经性别和年龄调整后的自然对数转换的 IgE 水平在乳腺癌患者或任何部位的癌症患者与其他亲属之间没有发现差异。计算了多基因和单基因座、双等位基因主基因和混合模型的可能性。该分析为 IgE 测定中存在多基因成分提供了证据；它没有显示出主要基因效应的证据。
Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex‐ and age‐adjusted natural logarithm‐transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one‐locus, two‐allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.