Cognitive performance and BMI in childhood: Shared genetic influences between reaction time but not response inhibition.
Cognitive performance and BMI in childhood: Shared genetic influences between reaction time but not response inhibition.
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DOI：
10.1002/oby.20862
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发表时间：
2014-11
期刊：
影响因子：
6.9
通讯作者：
Kuntsi, Jonna
中科院分区：
文献类型：
--
作者：
Frazier-Wood, Alexis C.;Carnell, Susan;Pena, Oscar;Hughes, Sheryl O.;O'Connor, Teresia M.;Asherson, Philip;Kuntsi, Jonna
这项工作的目的是了解共享的遗传影响是否可以解释肥胖和认知表现之间的关联，包括更慢和更可变的反应时间（RT）和更差的反应抑制。对1,312名7-10岁的双胞胎进行了四选择RT任务和go/no-go任务的RT测量，以及go/no-go任务的委托错误。BMI在9-12岁时测量。运行生物计量双胞胎模型，以估计体重指数（BMI）和三个认知指标之间的遗传相关性（rG）：平均RT（MRT），RT变异性（RTV; RT的标准差）和佣金错误（反应抑制的措施）。遗传相关性表明，20%-30%的BMI相关基因与两种RT指标相同。然而，只有小的表型之间的相关性MRT和RTV与后来的BMI（rPh = ~0.1）进行了观察。佣金错误与后来的BMI无关（rPh =-0.03，ns）。我们的研究结果是第一次证明RT性能和BMI之间存在显着的共享遗传效应。我们的研究结果为肥胖与更慢和更多变的RT相关的概念提供了生物学支持。然而，我们的研究结果也强调了这种关联的小性质，这可能解释了以前的负面研究结果。
The aim of this work is to understand whether shared genetic influences can explain the association between obesity and cognitive performance, including slower and more variable reaction times (RTs) and worse response inhibition. RT on a four-choice RT task and the go/no-go task, and commission errors on the go/no-go task for 1,312 twins ages 7-10 years were measured. BMI was measured at 9-12 years. Biometric twin models were run to give an estimate of the genetic correlation (rG) between body mass index (BMI) and three cognitive measures: mean RT (MRT), RT variability (RTV; the standard deviation of RTs), and commission errors (a measure of response inhibition). Genetic correlations indicated that 20%-30% of the genes underlying BMI were shared with both RT measures. However, only small phenotypic correlations between MRT and RTV with later BMI (rPh = ~0.1) were observed. Commission errors were unassociated with later BMI (rPh = −0.03, ns). Our results are the first to demonstrate significant shared genetic effects between RT performance and BMI. Our findings add biological support to the notion that obesity is associated with slower and more variable RTs. However, our results also emphasize the small nature of the association, which may explain previous negative findings.
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