Experimental application of thermosensitive paramagnetic liposomes for monitoring magnetic resonance imaging guided thermal ablation
Experimental application of thermosensitive paramagnetic liposomes for monitoring magnetic resonance imaging guided thermal ablation
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DOI：
10.1002/mrm.20289
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发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Gladhaug, I
中科院分区：
文献类型：
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作者：
Frich, L;Bjornerud, A;Gladhaug, I
在磁共振成像（MRI）引导的热疗消融期间，评价了在高于脂质体膜的相变温度（T-m）的温度下，T-1弛豫率显著增加的脂质体顺磁剂的使用。采用Nd-钇铝石榴石（Nd-YAG）激光器和射频消融系统对8只家兔肝脏进行了组织消融。在施用脂质体剂之前，在每只动物中进行一次消融。静脉注射T-m为57 ℃的含钆双胺（GdDTPA-BMA）的脂质体，并进行两次额外消融。在组织温度正常化后和组织温度正常化后15-20分钟，在加热的组织中进行T-1加权扫描。激光组和射频组在注射药剂前消融的信号强度增加（DeltaSI）分别为13.0%（SD = 5.7）和9.1%（SD = 7.9）。给予与加热无关的试剂后的信号强度无统计学显著性（DeltaSI = 1.4%，P = 0.35）。对于注射药物后进行的消融，激光组（DeltaSI = 34.5%，SID = 11.9）和射频组（DeltaSI = 21.6%，SID = 22.7）显著增加。在暴露于高于T-m的阈值温度的区域中发现的持续信号增强允许对MRI引导的热消融进行热监测。(C)2004 Wiley-Liss，Inc.
The use of a liposomal paramagnetic agent with a T-1-relaxivity that increases markedly at temperatures above the phase transition temperature (T-m) of the liposomal membrane was evaluated during magnetic resonance imaging (MRI) guided hyperthermia ablation. A neodymium-yttrium aluminum garnet (Nd-YAG) laser unit and a radiofrequency ablation system were used for tissue ablation in eight rabbit livers in vivo. One ablation was made in each animal prior to administration of the liposomal agent. Liposomes with a T-m of 57degreesC containing gadodiamide (GdDTPA-BMA) were injected iv, and two additional ablations were performed. T-1-weighted scans were performed in heated tissue, after tissue temperature had normalized, and 15-20 min after normalization of tissue temperature. Increase in signal intensity (DeltaSI) for ablations prior to injection of the agent was 13.0% (SD = 5.7) for the laser group and 9.1% (SD = 7.9) for the radiofrequency group. Signal intensity after administration of the agent unrelated to heating was not statistically significant (DeltaSI = 1.4%, P = 0.35). For ablations made after injection of the agent, a significant increase was found in the laser (DeltaSI = 34.5%, SID = 11.9) and radiofrequency group (DeltaSI = 21.6%, SID = 22.7). The persistent signal enhancement found in areas exposed to a temperature above the threshold temperature above T-m allows thermal monitoring of MRI guided thermal ablation. (C) 2004 Wiley-Liss, Inc.