WEIGHT GROWTH IN INFANTS BORN TO MOTHERS WHO SMOKED DURING PREGNANCY
WEIGHT GROWTH IN INFANTS BORN TO MOTHERS WHO SMOKED DURING PREGNANCY
复制标题
DOI：
10.1136/bmj.310.6982.768
复制
发表时间：
1995-03-25
影响因子：
--
通讯作者：
RIVA, L
中科院分区：
文献类型：
--
作者：
CONTER, V;CORTINOVIS, I;RIVA, L
研究目的：确定母亲在怀孕期间吸烟是否会对出生后的生长造成损害。设计：纵向研究。地点：意大利北部、中部和南部的6个城镇的6所医科大学中心。受试者：12987名婴儿（10238名出生于不吸烟的母亲，2276名出生于每天吸烟1至9支的母亲，473名来自每天吸烟超过或等于10支香烟的母亲）进入研究。主要结果测量-吸烟母亲和非吸烟母亲所生儿童体重增加的差异。在出生时以及3个月和6个月大时测量体重。母亲吸烟习惯来自分娩后第三或第四天的访谈。结果与母亲在怀孕期间不吸烟的儿童相比，母亲每天吸烟不超过9支的儿童出生体重分别低88 g（女孩）和107 g（男孩）;每天吸烟超过或等于10支的母亲所生的孩子体重分别低168克和247克。在第一组的6个月大时，女孩的平均体重比不吸烟母亲所生的孩子高9 g（95%置信区间为-47 g至65 g），男孩低64 g（-118 g至-10 g）。相应的数字为第二组分别为38克（-141克至85克）低的女孩和24克（-136克至88克）低的boy. Conclusions出生的母亲在怀孕期间吸烟的儿童出生时的体重不足，克服了6个月的年龄。当怀孕期间的吸烟习惯与其他不利变量（如较低的社会经济阶层）无关时，这些缺陷可能不是永久性的。
Objective-To determine whether maternal smoking during pregnancy causes impairment in grow-th after birth.Design-Longitudinal study.Setting-Six medical university centres of six towns of north, central, and south Italy.Subjects-12 987 babies (10 238 born from nonsmoking mothers, 2276 from mothers smoking one to nine cigarettes a day, and 473 from mothers smoking greater than or equal to 10 cigarettes a day) entered the study.Main outcome measures-Difference in weight gain between children born to smoking mothers and those born to non-smoking mothers. Weight was measured at birth and at 3 and 6 months of age. Maternal smoking habit was derived from interview on third or fourth day after delivery.Results-Compared with children born to mothers who did not smoke during pregnancy, the birth weights of children born to mothers who smoked up to nine cigarettes a day were 88 g (girls) and 107 g (boys) lower; in children born to mothers who smoked greater than or equal to 10 cigarettes a day weights were 168 g and 247 g lower. At six months of age for the first group the mean weight for girls was 9 g (95% confidence interval -47 g to 65 g) higher and for boys 64 g (-118 g to -10 g) lower than that of children born to mothers who did not smoke. The corresponding figures for the second group were 38 g (-141 g to 85 g) lower for girls and 24 g (-136 g to 88 g) lower for boys.Conclusions-The deficits of weight at birth in children born to mothers who smoked during pregnancy are overcome by 6 months of age. These deficits are probably not permanent when smoking habit during pregnancy is not associated with other unfavourable variables (such as lower socioeconomic class).