ON THE ROLES OF DIRECTED AND RANDOM CHANGES IN GENE FREQUENCY IN THE GENETICS OF POPULATIONS
ON THE ROLES OF DIRECTED AND RANDOM CHANGES IN GENE FREQUENCY IN THE GENETICS OF POPULATIONS
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DOI：
10.2307/2405519
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发表时间：
1948-01-01
期刊：
影响因子：
3.3
通讯作者：
WRIGHT, S
中科院分区：
文献类型：
--
作者：
WRIGHT, S
在以前的论文中，作者试图建立一个数学模型，同时考虑所有倾向于改变种群中基因频率的过程，并得出了关于最有利于进化的种群结构类型的结论。本文件试图澄清已经出现的误解，特别是在小规模、或多或少与世隔绝的人口中抽样的作用。第一次提出了基因频率的理论分布，从波动的方向和严重程度的选择和移民的数量和质量。与抽样结果的分布比较证实了后者在人口结构有利的情况下的重要性。然而，它表明，这些过程中的一个可能是更重要的某些基因，但另一个对其他基因，即使在同一人口。这些结论不同于费舍尔和福特（《遗传学》1：143-174）的结论（都是选择性差异的重要性），他们的结论是根据对Panaxia dominula蛾种群中特定基因频率波动的研究得出的。从本文的角度对他们的数据进行分析，即使是对于该基因的解释也令人怀疑。
In previous papers the author has attempted to formulate a mathematical model for simultaneous consideration of all processes that tend to change gene frequencies in a population and has drawn conclusions with respect to the type of population structure most favorable for evolution. The present paper is an attempt to clear up misapprehensions that have arisen, especially on the role of sampling in small, more or less isolated, populations. The theoretical distributions of gene frequencies resulting from fluctuations in the direction and severity of selection and in the amount and quality of immigration are presented for the first time. Comparison with the distributions resulting from sampling confirms the importance attributed to the latter where the population structure is favorable. It is shown, however, that one of these processes may be more important for certain genes, but another for other genes, even in the same population. These conclusions differ from those of Fisher and Ford (Heredity 1: 143-174) (all importance of selective differences) arrived at on the basis of a study of fluctuation in the frequency of a particular gene in a population of the moth Panaxia dominula. Analysis of their data from the point of view of this paper throws doubt on their interpretation even with respect to this gene.