Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: Clinical and immunologic correlates
Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: Clinical and immunologic correlates
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DOI：
10.1086/514045
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发表时间：
1997-07-01
影响因子：
6.4
通讯作者：
Corey, L
中科院分区：
文献类型：
--
作者：
Koelle, DM;Huang, ML;Corey, L
研究了唾液中卡波西肉瘤（KS）相关疱疹病毒（KSHV;或人疱疹病毒[HHV]-8）DNA脱落的患病率、数量、时间模式以及临床和免疫学相关性。24例人类免疫缺陷病毒（HIV）阳性KS患者中有18例（75%）唾液中检测到KSHV DNA，1例HIV阴性KS患者中有1例唾液中检测到KSHV DNA，20例HIV阳性但无KS患者中有3例（15%）唾液中检测到KSHV DNA，24例对照中无KSHV DNA。KSHV DNA水平范围为10（2.4）至10（6）拷贝/mL，低于EB病毒水平，但与HHV-6相当。唾液中KSHV DNA的检出与口腔KS或外周血CD_4细胞计数的降低无关，精液中未检出KSHV DNA，唾液中KSHV DNA对DNA酶处理的抗性与病毒粒子的存在一致。这些数据表明KSHV可以在口咽部复制，唾液接触可能有助于KSHV的传播。
The prevalence, quantity, temporal pattern, and clinical and immunologic correlates of shedding of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV; or human herpesvirus [HHV]-8) DNA in saliva were studied. KSHV DNA was detected in saliva from 18 (75%) of 24 human immunodeficieney virus (HIV)-positive patients with KS and from 1 of 1 HIV-negative patient with KS, 3 (15%) of 20 HIV-positive patients without KS, and none of 24 controls, KSHV DNA levels ranged from 10(2.4) to 10(6) copies/mL and were lower than levels far Epstein-Barr virus but comparable to those for HHV-6. Detection of KSHV DNA in saliva was not associated with oral KS or decreased peripheral blood CD4 cell counts, KSHV DNA was not detected in semen, Resistance of KSHV DNA from saliva to DNase treatment was consistent with the presence of virions, These data suggest that KSHV can replicate in the oropharynx and that salivary contact could contribute to KSHV transmission.