Elevated serum aminotransferase level as a predictor of intracerebral hemorrhage - Korea Medical Insurance Corporation Study
Elevated serum aminotransferase level as a predictor of intracerebral hemorrhage - Korea Medical Insurance Corporation Study
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DOI：
10.1161/01.str.0000173404.37692.9b
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发表时间：
2005-08-01
期刊：
影响因子：
8.3
通讯作者：
Suh, I
中科院分区：
文献类型：
--
作者：
Kim, HC;Kang, DR;Suh, I
背景和目的-血清转氨酶水平已知与心血管危险因素相关，但与卒中发生率的关系尚不清楚。我们调查了血清氨基转移酶水平与中风发病率之间的关系。方法-我们于1990年和1992年测量了108464名年龄在35至59岁之间的韩国男性的血清天冬氨酸和丙氨酸氨基转移酶水平以及传统心血管危险因素。血清转氨酶水平分为3类（≥ 70 IU/L）。结果：1993年至2002年，缺血性卒中、脑内出血（ICH）和蛛网膜下腔出血（SAH）共发生1728例，出血性卒中（718例ICH和222例SAH）共1051例，不明原因卒中共243例。校正年龄和其他传统危险因素后，根据考克斯比例风险模型，血清转氨酶水平与ICH有独立的正相关性。然而，缺血性卒中和SAH与转氨酶水平无关。与水平= 70 IU/L相比，分别为1.49（1.21 ~ 1.83）和4.21（3.06 ~ 5.77）。丙氨酸氨基转移酶的相应风险分别为1.34（1.09至1.65）和2.89（2.09至4.01）。这些协会是一致的，无论肥胖水平，血压，空腹血糖，酒精摄入量和后续longs.Conclusions -这些研究结果表明，转氨酶水平升高是ICH的预测因子。转氨酶水平在脑出血发生发展中的生物学意义值得进一步研究。
Background and Purpose - Serum aminotransferase levels are known to be associated with cardiovascular risk factors, but the relation with stroke incidence is not well known. We investigated the relation between serum aminotransferase levels and the incidence of stroke.Methods - We measured serum aspartate and alanine aminotransferase levels and traditional cardiovascular risk factors in 108 464 Korean men, aged 35 to 59 years, in 1990 and 1992. Serum aminotransferase levels were classified into 3 categories (= 70 IU/L). The outcomes were hospital admissions and deaths from stroke subtypes (ischemic stroke, intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) from 1993 to 2002.Results - During the 10 years, 1728 ischemic, 1051 hemorrhagic (718 ICH and 222 SAH), and 243 unspecified stroke events occurred. After adjustment for age and other traditional risk factors and according to Cox proportional-hazards models, serum aminotransferase level had an independent positive associations with ICH. However, ischemic stroke and SAH were not associated with aminotransferase levels. Compared with the level = 70 IU/L were 1.49 (1.21 to 1.83) and 4.21 (3.06 to 5.77), respectively. The corresponding risks for alanine aminotransferase were 1.34 (1.09 to 1.65) and 2.89 (2.09 to 4.01), respectively. These associations were consistent regardless of the level of obesity, blood pressure, fasting glucose, alcohol intake, and follow-up length.Conclusions - These findings suggest that an elevated aminotransferase level is a predictor of ICH. The biologic significance of aminotransferase level for the development of ICH merits further study.