Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis
Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis
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DOI：
10.1080/23723556.2019.1699375
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发表时间：
2019-12-12
影响因子：
2.1
通讯作者：
Chi, Jen-Tsan
中科院分区：
文献类型：
--
作者：
Yang, Wen-Hsuan;Chi, Jen-Tsan
铁下垂是一种新型的程序性细胞死亡。我们发现肾癌和卵巢癌的铁下垂敏感性分别通过TAZ-EMP1-NOX4和TAZ-ANGPTL4-NOX2途径由细胞密度调节。这些发现揭示了TAZ是一种新的铁性下垂的遗传决定因素。引发铁下垂可能对TAZ激活的肿瘤有治疗潜力。
Ferroptosis a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Triggering ferroptosis may have therapeutic potential for TAZ-activated tumors.