A phosphatase associated with metastasis of colorectal cancer
A phosphatase associated with metastasis of colorectal cancer
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DOI：
10.1126/science.1065817
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发表时间：
2001-11-09
期刊：
影响因子：
56.9
通讯作者：
Vogelstein, B
中科院分区：
文献类型：
--
作者：
Saha, S;Bardelli, A;Vogelstein, B
为了深入了解转移的分子基础，我们比较了转移性结直肠癌与原发癌、良性结直肠肿瘤和正常结直肠上皮的整体基因表达谱。在所鉴定的基因中，PRL-3蛋白酪氨酸磷酸酶基因是特别感兴趣的。它在18个研究的癌转移灶中均以高水平表达，但在非转移性肿瘤和正常结直肠上皮中以低水平表达。在3的12个转移检查，PRL-3基因的多个拷贝被发现在一个小的扩增子位于染色体8q24.3。这些数据表明，PRL-3基因是重要的大肠癌转移，并提供了一个新的治疗目标，这些难治性病变。
To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.