Use of preferentially replicating bacteria for the treatment of cancer
Use of preferentially replicating bacteria for the treatment of cancer
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DOI：
10.1172/jci9818
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发表时间：
2000-04-01
影响因子：
15.9
通讯作者：
King, I
中科院分区：
文献类型：
--
作者：
Sznol, M;Lin, SL;King, I
大约40年前，观察到实验动物肿瘤内的条件可能有利于细菌的优先复制。或者，在转移模型的情况下，在建立小的肺转移后(11)，大多数模型的肿瘤生长被长期抑制，在某些情况下可达50-60天。其中几个模型显示存活时间有所改善，但肿瘤最终恢复生长，导致动物死亡。在严格厌氧菌的临床前研究中，没有观察到与肿瘤部位相关的全身毒性，尽管在较长时间后，一些皮下肿瘤形成了中央坏死区。
About 40 years ago, the observation was made that conditions within experimental animal tumors could favor the preferential replication of bacteria.9, 10) or, in the case of metastatic models, after small lung metastases were established (11), tumor growth was inhibited in most models for prolonged periods, in some cases up to 50–60 days. Several of the models showed improved survival times, but tumors eventually resumed growth, resulting in the death of the animals. The tumor site-related and systemic toxicities reported in preclinical studies of strictly anaerobic bacteria were not observed, although after a prolonged period, some subcutaneous tumors developed a central necrotic region.