Abnormal Functional Hierarchies of EEG Networks in Familial and Sporadic Prodromal Alzheimer's Disease During Visual Short-Term Memory Binding.
Abnormal Functional Hierarchies of EEG Networks in Familial and Sporadic Prodromal Alzheimer's Disease During Visual Short-Term Memory Binding.
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DOI：
10.3389/fnimg.2022.883968
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发表时间：
2022
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影响因子：
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通讯作者：
Parra, Mario A
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作者：
Smith, Keith M;Starr, John M;Escudero, Javier;Ibanez, Agustin;Parra, Mario A
阿尔茨海默病 (AD) 表现出大脑区域之间功能依赖性的复杂改变以及执行视觉短期记忆结合 (VSTMB) 任务的能力下降。网络神经科学在理解分层大脑功能的复杂性方面的最新进展使我们能够在这两种现象之间建立联系。在这里，我们研究了两种类型的轻度认知障碍 (MCI) 阶段痴呆症的数据：家族性 AD 患者（早老素 1 基因的 E280A 突变）和散发性 AD 高风险的老年 MCI 患者，两者均具有年龄匹配的对照。我们分析了这些参与者在执行视觉短期记忆（VSTM）任务期间记录的脑电图（EEG）信号。使用 Alpha 和 Beta 中的相位滞后指数计算功能连接；并使用层次分布（程度方差）和复杂性的网络指数进行网络分析。 EEG功能连接网络的层次特征揭示了家族性MCI VSTMB功能和散发性MCI VSTMB功能的异常模式。与健康对照相比，中年家族性MCI结合网络在较低的Beta方面表现出更大的程度方差（p = 0.0051，Cohen's d = 1.0124），而老年散发性MCI结合网络在Alpha方面表现出更大的层次复杂性（p = 0.0140，Cohen's d = 1.1627）。健康老龄化的特征没有显示出差异。这些结果表明，MCI 中的活动表现出跨频率网络重组，其特征是功能层次结构中节点角色的异质性增加。未发现老化本身会导致 VSTM 功能层次差异。
Alzheimer's Disease (AD) shows both complex alterations of functional dependencies between brain regions and a decreased ability to perform Visual Short-Term Memory Binding (VSTMB) tasks. Recent advances in network neuroscience toward understanding the complexity of hierarchical brain function here enables us to establish a link between these two phenomena. Here, we study data on two types of dementia at Mild Cognitive Impairment (MCI) stage—familial AD patients (E280A mutation of the presenilin-1 gene) and elderly MCI patients at high risk of sporadic AD, both with age-matched controls. We analyzed Electroencephalogram (EEG) signals recorded during the performance of Visual Short-Term Memory (VSTM) tasks by these participants. Functional connectivity was computed using the phase-lag index in Alpha and Beta; and network analysis was employed using network indices of hierarchical spread (degree variance) and complexity. Hierarchical characteristics of EEG functional connectivity networks revealed abnormal patterns in familial MCI VSTMB function and sporadic MCI VSTMB function. The middle-aged familial MCI binding network displayed a larger degree variance in lower Beta compared to healthy controls (p = 0.0051, Cohen's d = 1.0124), while the elderly sporadic MCI binding network displayed greater hierarchical complexity in Alpha (p = 0.0140, Cohen's d = 1.1627). Characteristics in healthy aging were not shown to differ. These results indicate that activity in MCI exhibits cross-frequency network reorganization characterized by increased heterogeneity of node roles in the functional hierarchy. Aging itself is not found to cause VSTM functional hierarchy differences.