Total synthesis of agelagalastatin.
Total synthesis of agelagalastatin.
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DOI：
10.1021/ol061444o
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发表时间：
2006-08
期刊：
影响因子：
5.2
通讯作者：
Yong Joo Lee;Bo-Young Lee;H. Jeon;K. Kim
中科院分区：
文献类型：
--
作者：
Yong Joo Lee;Bo-Young Lee;H. Jeon;K. Kim
成功地合成了一种抗肿瘤糖鞘糖脂--琼脂糖凝胶。该合成涉及神经酰胺部分与三糖氟化物的α-选择性糖基化。三糖组分是采用CB糖苷法构建的，这种方法允许完全α-立体选择性的呋喃半乳糖基化。
The total synthesis of agelagalastatin, an antineoplastic glycosphingolipid, has been achieved. The synthesis involved an alpha-selective glycosylation of the ceramide moiety with the trisaccharide fluoride. The trisaccharide component was constructed employing the CB glycoside method which permitted a completely alpha-stereoselective galactofuranosylation.