Distinct subsets of regulatory T cells during pregnancy: Is the imbalance of these subsets involved in the pathogenesis of preeclampsia?
Distinct subsets of regulatory T cells during pregnancy: Is the imbalance of these subsets involved in the pathogenesis of preeclampsia?
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DOI：
10.1016/j.clim.2008.07.032
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发表时间：
2008-12-01
影响因子：
8.6
通讯作者：
Sohn, Christof
中科院分区：
文献类型：
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作者：
Steinborn, Andrea;Haensch, Gertrud M.;Sohn, Christof
调节性T细胞（CD 4（+）CD 25（+）FoxP 3（+）-Treg细胞）是妊娠期间耐受诱导的重要调节因子。我们现在发现，在正常妊娠过程中，CD 4（+）CD 25（+）FoxP 3（+）-Treg细胞的数量减少，在先兆子痫患者中更是如此。与健康受试者相比，这些CD 4（+）CD 25（+）-Treg细胞的功能活性显著降低。进一步的分析揭示了两个Treg亚群，其在FoxP 3和CD 25表达方面不同。CD 4（+）CD 25（+）FoxP 3（高+）-Treg和CD 4（+）CD 25（高+）FoxP 3（+）的百分比最大。在第一和第二三角区，但在第三三角区严重下降。在先兆子痫妇女中，CD 4（+）CD 25（高+）FoxP 3（+）-Treg细胞的群体特别明显，而CD 4（+）CD 25（+）FoxP 3（高+）-Treg细胞的群体显著减少。我们认为，CD 4（+）CD 25（+）FoxP 3（高+）-和CD 4（+）CD 25（高+）FoxP 3（+）-Treg细胞群代表不同的Treg细胞亚群，这两种Treg细胞亚群平衡的紊乱与先兆子痫的存在有关，但与HELLP综合征无关。(C)2008年爱思唯尔公司All rights reserved.
Regulatory T cells (CD4(+)CD25(+)FoxP3(+)-Treg cells) are important regulators of tolerance induction during pregnancy. We now found that the number of CD4(+)CD25(+)FoxP3(+)-Treg cells decreases during normal course of pregnancy and even more so in women affected by preeclampsia. The functional activity of these CD4(+)CD25(+)-Treg cells was significantly reduced in comparison to those of healthy pregnants. Further analysis revealed two Treg subsets that differed with regard to the FoxP3 and CD25 expression. The percentage of both, CD4(+)CD25(+)FoxP3(high+)-Treg and CD4(+)CD25(high+)FoxP3(+), was maximal. in the first and second trimenon, but declined severely in the third trimenon. In preeclamptic women the population of CD4(+)CD25(high+)FoxP3(+)-Treg cells was particularly apparent, while the population of CD4(+)CD25(+)FoxP3(high+)-Treg cells was significantly decreased. We propose that CD4(+)CD25(+)FoxP3(high+)- and CD4(+)CD25(high+)FoxP3(+)-Treg cell populations represent distinct Treg cell subsets, and that disturbances in the balance of these two Treg cell subsets are associated with the presence of preeclampsia, but not HELLP-syndrome. (C) 2008 Elsevier Inc. All rights reserved.