Lethal Ischemic Stroke after Cisplatin-Based Chemotherapy for Testicular Carcinoma and Cannabis Inhalation
Lethal Ischemic Stroke after Cisplatin-Based Chemotherapy for Testicular Carcinoma and Cannabis Inhalation
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睾丸癌顺铂化疗和大麻吸入后发生致命性缺血性中风
DOI：
10.1159/000065511
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发表时间：
2002
影响因子：
2.4
通讯作者：
C. Bassetti
中科院分区：
文献类型：
--
作者：
S. Russmann;A. Winkler;K. Lövblad;Z. Stanga;C. Bassetti
恶性疾病作为脑血管疾病危险因素的作用已得到充分证实。血管炎、肿瘤栓塞、非细菌性心内膜炎和凝血功能障碍是最常见的。不太常见的是，中风风险的增加也可能是由于化疗的血管毒性所致。在至少15例患者中，顺铂类化疗与缺血性脑卒中之间存在特殊关联[3-9]。潜在的机制仍然是推测性的，到目前为止还没有明确确定风险因素。在少数患者中，也报道了大麻吸入与卒中bbb之间的密切时间关系。据我们所知，化疗和吸入大麻后中风从未有过报道。
The role of malignant disease as a risk factor for cerebrovascular disorders is well established [1]. Vasculitis, tumor embolization, nonbacterial endocarditis, and coagulopathy are most commonly involved. Less commonly, the increased stroke risk may also be due to the vascular toxicity of chemotherapy [2]. A particular association was suggested between cisplatin-based chemotherapy and ischemic stroke in at least 15 patients [3–9]. The underlying mechanisms remain speculative and risk factors have not been clearly identified so far. In a few patients, a close temporal relationship was also reported between cannabis inhalation and stroke [10]. To our best knowledge, stroke following chemotherapy and cannabis inhalation has never been reported before.